Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 1276495..1277099 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag FPJ87_RS05915 Protein ID WP_003414492.1
Coordinates 1276707..1277099 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag FPJ87_RS05910 Protein ID WP_003414495.1
Coordinates 1276495..1276710 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS05885 1271497..1272408 + 912 WP_003414505.1 sugar ABC transporter permease -
FPJ87_RS05890 1272405..1273232 + 828 WP_003414504.1 carbohydrate ABC transporter permease -
FPJ87_RS05895 1273235..1274545 + 1311 WP_003414501.1 ABC transporter substrate-binding protein -
FPJ87_RS05900 1274538..1275620 + 1083 WP_003414499.1 ABC transporter ATP-binding protein -
FPJ87_RS05905 1275699..1276448 - 750 WP_003414497.1 enoyl-CoA hydratase -
FPJ87_RS05910 1276495..1276710 + 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPJ87_RS05915 1276707..1277099 + 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ87_RS05920 1277120..1277389 + 270 WP_003414489.1 DUF2277 family protein -
FPJ87_RS05925 1277386..1277931 + 546 WP_009939112.1 DUF1802 family protein -
FPJ87_RS05930 1278236..1279123 + 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
FPJ87_RS05935 1279126..1280010 + 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FPJ87_RS05940 1280282..1280827 + 546 WP_003913758.1 DUF1802 family protein -
FPJ87_RS05945 1281161..1281949 + 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T139705 WP_003414492.1 NZ_CP043995:1276707-1277099 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T139705 NZ_CP058786:1851621-1851872 [Shigella flexneri]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT139705 WP_003414495.1 NZ_CP043995:1276495-1276710 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT139705 NZ_CP058786:1851869-1852123 [Shigella flexneri]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References