Detailed information of TA system TA139689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 446984..447995
• Replicon: chromosome
• Accession: NZ_CP043995
• Organism: Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A655I6S7
• Locus tag: FPJ87_RS01920
• Protein ID: WP_003906352.1
• Coordinates: 446984..447577 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: O53702
• Locus tag: FPJ87_RS01925
• Protein ID: WP_003401860.1
• Coordinates: 447606..447995 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ87_RS01900	442633..444015	+	1383	WP_003898415.1	magnesium transporter	-
FPJ87_RS01905	444027..445061	-	1035	WP_003401856.1	class II fructose-bisphosphate aldolase	-
FPJ87_RS01910	445157..445840	+	684	WP_003401857.1	VTT domain-containing protein	-
FPJ87_RS01915	445829..446959	-	1131	WP_003401858.1	hypothetical protein	-
FPJ87_RS01920	446984..447577	-	594	WP_003906352.1	zeta toxin family protein	Toxin
FPJ87_RS01925	447606..447995	-	390	WP_003401860.1	hypothetical protein	Antitoxin
FPJ87_RS01930	448076..449287	-	1212	WP_003906353.1	VWA domain-containing protein	-
FPJ87_RS01935	449293..449895	-	603	WP_003898417.1	SRPBCC family protein	-
FPJ87_RS01940	449909..450805	-	897	WP_003898418.1	MoxR family ATPase	-
FPJ87_RS01945	450802..451395	-	594	WP_003401864.1	NTP transferase domain-containing protein	-
FPJ87_RS01950	451392..452147	-	756	WP_003401865.1	XdhC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21358.60 Da
• Isoelectric Point: 10.6337

>T139689 WP_003906352.1 NZ_CP043995:c447577-446984 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDKSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

>T139689 NZ_CP058780:2616352-2616459 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13648.21 Da
• Isoelectric Point: 6.0829

>AT139689 WP_003401860.1 NZ_CP043995:c447995-447606 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

>AT139689 NZ_CP058780:c2616305-2616241 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A655I6S7

Antitoxin

• AlphaFold DB: A0A7U4BRT0