Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 446984..447995 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name pezT Uniprot ID A0A655I6S7
Locus tag FPJ87_RS01920 Protein ID WP_003906352.1
Coordinates 446984..447577 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag FPJ87_RS01925 Protein ID WP_003401860.1
Coordinates 447606..447995 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS01900 442633..444015 + 1383 WP_003898415.1 magnesium transporter -
FPJ87_RS01905 444027..445061 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
FPJ87_RS01910 445157..445840 + 684 WP_003401857.1 VTT domain-containing protein -
FPJ87_RS01915 445829..446959 - 1131 WP_003401858.1 hypothetical protein -
FPJ87_RS01920 446984..447577 - 594 WP_003906352.1 zeta toxin family protein Toxin
FPJ87_RS01925 447606..447995 - 390 WP_003401860.1 hypothetical protein Antitoxin
FPJ87_RS01930 448076..449287 - 1212 WP_003906353.1 VWA domain-containing protein -
FPJ87_RS01935 449293..449895 - 603 WP_003898417.1 SRPBCC family protein -
FPJ87_RS01940 449909..450805 - 897 WP_003898418.1 MoxR family ATPase -
FPJ87_RS01945 450802..451395 - 594 WP_003401864.1 NTP transferase domain-containing protein -
FPJ87_RS01950 451392..452147 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21358.60 Da        Isoelectric Point: 10.6337

>T139689 WP_003906352.1 NZ_CP043995:c447577-446984 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDKSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T139689 NZ_CP058780:2616352-2616459 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT139689 WP_003401860.1 NZ_CP043995:c447995-447606 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT139689 NZ_CP058780:c2616305-2616241 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A655I6S7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References