Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 366582..367225 | Replicon | chromosome |
Accession | NZ_CP043995 | ||
Organism | Mycobacterium tuberculosis strain 4-0041P6C4 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFB8 |
Locus tag | FPJ87_RS01600 | Protein ID | WP_003401566.1 |
Coordinates | 366800..367225 (+) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | O07227 |
Locus tag | FPJ87_RS01595 | Protein ID | WP_003401563.1 |
Coordinates | 366582..366803 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FPJ87_RS01570 | 361710..362513 | - | 804 | WP_003401540.1 | hypothetical protein | - |
FPJ87_RS01575 | 362523..363920 | - | 1398 | WP_003401544.1 | sulfatase | - |
FPJ87_RS01580 | 364099..365865 | + | 1767 | WP_014297570.1 | PE family protein | - |
FPJ87_RS01585 | 366008..366235 | + | 228 | WP_003401555.1 | ribbon-helix-helix protein, CopG family | - |
FPJ87_RS01590 | 366232..366534 | + | 303 | WP_003401560.1 | toxin-antitoxin system toxin | - |
FPJ87_RS01595 | 366582..366803 | + | 222 | WP_003401563.1 | type II toxin-antitoxin system antitoxin VapB2 | Antitoxin |
FPJ87_RS01600 | 366800..367225 | + | 426 | WP_003401566.1 | PIN domain nuclease | Toxin |
FPJ87_RS01605 | 367361..367993 | + | 633 | WP_003401571.1 | TetR/AcrR family transcriptional regulator | - |
FPJ87_RS01610 | 367990..368898 | + | 909 | WP_003900117.1 | SDR family NAD(P)-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15713.90 Da Isoelectric Point: 5.6002
>T139688 WP_003401566.1 NZ_CP043995:366800-367225 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA
Download Length: 426 bp
>T139688 NZ_CP058780:2615817-2615924 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8088.31 Da Isoelectric Point: 10.7177
>AT139688 WP_003401563.1 NZ_CP043995:366582-366803 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
Download Length: 222 bp
>AT139688 NZ_CP058780:c2615770-2615704 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 3H87 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 3H87 | |
AlphaFold DB | A0A829CG48 |