Detailed information of TA system TA139678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 6082877..6083442
• Replicon: chromosome
• Accession: NZ_CP043959
• Organism: Streptomyces tendae strain 139

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: F3L20_RS27930
• Protein ID: WP_150156665.1
• Coordinates: 6082877..6083245 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: F3L20_RS27935
• Protein ID: WP_150156666.1
• Coordinates: 6083245..6083442 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3L20_RS27910	6078150..6079073	+	924	WP_150157524.1	glycine betaine ABC transporter substrate-binding protein	-
F3L20_RS27915	6079086..6079877	-	792	WP_150156663.1	hypothetical protein	-
F3L20_RS27920	6079970..6080611	-	642	WP_145827539.1	helix-turn-helix domain-containing protein	-
F3L20_RS27925	6080959..6082752	-	1794	WP_206338829.1	DEAD/DEAH box helicase family protein	-
F3L20_RS27930	6082877..6083245	-	369	WP_150156665.1	Fic family protein	Toxin
F3L20_RS27935	6083245..6083442	-	198	WP_150156666.1	hypothetical protein	Antitoxin
F3L20_RS27940	6083475..6084941	-	1467	WP_150156667.1	MFS transporter	-
F3L20_RS27955	6085610..6086788	-	1179	WP_150156668.1	SUKH-4 family immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (12-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13764.68 Da
• Isoelectric Point: 4.8888

>T139678 WP_150156665.1 NZ_CP043959:c6083245-6082877 [Streptomyces tendae]
MYHLTLPELLNLAKRLGEEAVRDYGLLDSALARPQSSVFGQDAYPDVWQKAAALMESLARNHALVDGNKRLAWYATWVFL
HMNGHPLDPEFDVDEAERFVLDVCQGALDVPKIASELPRFAR

Nucleotide

• Length: 369 bp

>T139678 NZ_CP058780:c562468-562004 [Shigella flexneri]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7147.98 Da
• Isoelectric Point: 5.5590

>AT139678 WP_150156666.1 NZ_CP043959:c6083442-6083245 [Streptomyces tendae]
MAGLNLRFTDDELDALRERAAAEGRSMQAFAHDAVVAAINEHSRLFNEAADHVLKASAELNRRLA

Nucleotide

• Length: 198 bp

>AT139678 NZ_CP058780:c562803-562468 [Shigella flexneri]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA