Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 158091..158725 Replicon chromosome
Accession NZ_CP043959
Organism Streptomyces tendae strain 139

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F3L20_RS00750 Protein ID WP_150151038.1
Coordinates 158091..158513 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F3L20_RS00755 Protein ID WP_150151040.1
Coordinates 158510..158725 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3L20_RS00720 153795..154298 + 504 WP_150151023.1 lamin tail domain-containing protein -
F3L20_RS00725 154432..155265 - 834 WP_150151026.1 PIG-L family deacetylase -
F3L20_RS00730 156059..156505 + 447 WP_150151029.1 SRPBCC family protein -
F3L20_RS00735 156804..157025 + 222 WP_206338842.1 type II toxin-antitoxin system VapB family antitoxin -
F3L20_RS00740 157022..157432 + 411 WP_150151035.1 PIN domain-containing protein -
F3L20_RS00750 158091..158513 - 423 WP_150151038.1 PIN domain nuclease Toxin
F3L20_RS00755 158510..158725 - 216 WP_150151040.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
F3L20_RS00760 159176..159985 - 810 WP_150151043.1 GntR family transcriptional regulator -
F3L20_RS00765 160066..160350 + 285 WP_150151046.1 hypothetical protein -
F3L20_RS00780 160825..161121 + 297 WP_150151055.1 hypothetical protein -
F3L20_RS00785 161081..161821 + 741 WP_167534431.1 GntR family transcriptional regulator -
F3L20_RS00790 161818..162123 + 306 WP_150151058.1 hypothetical protein -
F3L20_RS00795 162424..162831 - 408 WP_181007385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-49)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15374.19 Da        Isoelectric Point: 4.5626

>T139677 WP_150151038.1 NZ_CP043959:c158513-158091 [Streptomyces tendae]
VNAAQFLIDTSALARLLRGDAEQYGWDQATAAGLIATCPITELEFFYSARSAADRAQGIEDLRLLFGWVPVDDRAYDRAW
QVQDTLTQRGHHRSAGAVDLVVAATAELQGLTLLHRDRDFECIAAVTGQALQWYGPEPGK

Download         Length: 423 bp

>T139677 NZ_CP058780:166757-166864 [Shigella flexneri]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7889.97 Da        Isoelectric Point: 8.6595

>AT139677 WP_150151040.1 NZ_CP043959:c158725-158510 [Streptomyces tendae]
MTRTVIDLDDQLVADVAKALGTSTKKETVNTALREVLESRRRALALTRLRAASAEGAFDLDLLEDKGNYRR

Download         Length: 216 bp

>AT139677 NZ_CP058780:c166709-166643 [Shigella flexneri]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References