Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 920937..921563 Replicon chromosome
Accession NZ_CP043955
Organism Morganella morganii subsp. morganii strain 171229813

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag F3L16_RS04250 Protein ID WP_024474604.1
Coordinates 920937..921140 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag F3L16_RS04255 Protein ID WP_004236473.1
Coordinates 921204..921563 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3L16_RS04230 917493..917831 + 339 WP_004236467.1 P-II family nitrogen regulator -
F3L16_RS04235 917851..919140 + 1290 WP_036422539.1 ammonium transporter AmtB -
F3L16_RS04240 919201..920064 - 864 WP_062771844.1 acyl-CoA thioesterase II -
F3L16_RS04250 920937..921140 - 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
F3L16_RS04255 921204..921563 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
F3L16_RS04260 922126..925302 - 3177 WP_004240375.1 multidrug efflux RND transporter permease subunit -
F3L16_RS04265 925317..926513 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T139674 WP_024474604.1 NZ_CP043955:c921140-920937 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T139674 NZ_CP058780:165308-165415 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT139674 WP_004236473.1 NZ_CP043955:c921563-921204 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT139674 NZ_CP058780:c165251-165194 [Shigella flexneri]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References