Detailed information of TA system TA139673

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 446608..447249
• Replicon: chromosome
• Accession: NZ_CP043953
• Organism: Acinetobacter baumannii strain K09-14

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A1S2G112
• Locus tag: F3P16_RS02185
• Protein ID: WP_071210859.1
• Coordinates: 446860..447249 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: F3P16_RS02180
• Protein ID: WP_011860336.1
• Coordinates: 446608..446853 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3P16_RS02160	442111..443118	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
F3P16_RS02165	443137..443514	+	378	WP_001216380.1	50S ribosomal protein L17	-
F3P16_RS02170	443696..445186	+	1491	WP_016686239.1	NAD(P)/FAD-dependent oxidoreductase	-
F3P16_RS02175	445236..446408	-	1173	WP_071210858.1	acyl-CoA dehydrogenase family protein	-
F3P16_RS02180	446608..446853	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
F3P16_RS02185	446860..447249	+	390	WP_071210859.1	hypothetical protein	Toxin
F3P16_RS02190	448019..449104	+	1086	WP_000049106.1	hypothetical protein	-
F3P16_RS02195	449183..449749	+	567	WP_000651536.1	rhombosortase	-
F3P16_RS02200	449937..452132	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15690.01 Da
• Isoelectric Point: 10.4623

>T139673 WP_071210859.1 NZ_CP043953:446860-447249 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T139673 NZ_CP058773:c21350-20970 [Shigella flexneri]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACGGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGTATACAGGTATATGATTCACCTGAACTGGCAGACCTTACTGTAGGTGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTTCGGAGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT139673 WP_011860336.1 NZ_CP043953:446608-446853 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT139673 NZ_CP058773:c21571-21350 [Shigella flexneri]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGAGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTTGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: A0A1S2G112