Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2367359..2367837 Replicon chromosome
Accession NZ_CP043950
Organism Escherichia coli strain ST95-32

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag F3J96_RS11890 Protein ID WP_000936799.1
Coordinates 2367359..2367646 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag F3J96_RS11895 Protein ID WP_000100899.1
Coordinates 2367646..2367837 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3J96_RS11840 2362406..2363149 + 744 WP_000140762.1 C40 family peptidase -
F3J96_RS11845 2363086..2363688 + 603 WP_000090879.1 tail assembly protein -
F3J96_RS27790 2363762..2364100 + 339 WP_001332187.1 hypothetical protein -
F3J96_RS11855 2364167..2364499 + 333 Protein_2258 host specificity protein J -
F3J96_RS11860 2364655..2364876 - 222 WP_000560231.1 cell division protein FtsZ -
F3J96_RS11865 2364922..2365770 - 849 WP_000935606.1 Rha family phage regulatory protein -
F3J96_RS11875 2366338..2366559 + 222 WP_000202161.1 hypothetical protein -
F3J96_RS11880 2366549..2366923 - 375 WP_001553098.1 hypothetical protein -
F3J96_RS11885 2366935..2367087 - 153 WP_000379609.1 DUF1391 family protein -
F3J96_RS11890 2367359..2367646 - 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3J96_RS11895 2367646..2367837 - 192 WP_000100899.1 hypothetical protein Antitoxin
F3J96_RS11900 2367865..2368266 - 402 WP_001329851.1 helix-turn-helix domain-containing protein -
F3J96_RS11905 2368376..2368648 + 273 WP_000887447.1 helix-turn-helix domain-containing protein -
F3J96_RS11910 2368632..2368910 + 279 Protein_2268 toxin YdaT domain-containing protein -
F3J96_RS27795 2368919..2369164 + 246 Protein_2269 hypothetical protein -
F3J96_RS27800 2369313..2369510 + 198 Protein_2270 host specificity protein J -
F3J96_RS11925 2370200..2371215 + 1016 Protein_2271 DUF1983 domain-containing protein -
F3J96_RS11930 2371218..2371817 + 600 WP_001233195.1 Ail/Lom family outer membrane beta-barrel protein -
F3J96_RS11935 2371969..2372247 + 279 Protein_2273 prophage tail fiber N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2322755..2372361 49606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T139635 WP_000936799.1 NZ_CP043950:c2367646-2367359 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T139635 NZ_CP058758:777803-778213 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT139635 WP_000100899.1 NZ_CP043950:c2367837-2367646 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT139635 NZ_CP058758:777556-777822 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References