Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 58112..58659 Replicon plasmid pMPTEM-30
Accession NZ_CP043947
Organism Escherichia coli strain AR202.2

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag F3P13_RS23765 Protein ID WP_000970007.1
Coordinates 58378..58659 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag F3P13_RS23760 Protein ID WP_000079941.1
Coordinates 58112..58381 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3P13_RS23715 53756..54289 - 534 WP_001303319.1 transcription termination factor NusG -
F3P13_RS23725 54731..55018 - 288 WP_000074849.1 conjugal transfer protein TraA -
F3P13_RS23730 54936..55199 - 264 WP_001324596.1 ash family protein -
F3P13_RS23745 56172..57203 + 1032 WP_000907873.1 replication initiation protein -
F3P13_RS25500 57899..58057 + 159 WP_000841008.1 hypothetical protein -
F3P13_RS23760 58112..58381 + 270 WP_000079941.1 hypothetical protein Antitoxin
F3P13_RS23765 58378..58659 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3P13_RS23770 58699..59547 + 849 WP_001057996.1 3'-5' exonuclease -
F3P13_RS23775 59664..60137 + 474 WP_001334658.1 hypothetical protein -
F3P13_RS23785 60614..60880 - 267 WP_000955263.1 hypothetical protein -
F3P13_RS23790 60880..61374 - 495 WP_001459505.1 hypothetical protein -
F3P13_RS23795 61430..62032 - 603 WP_000517695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / floR / blaTEM-30 / sul1 / qacE / ant(3'')-Ia / dfrA1 - 1..115932 115932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T139605 WP_000970007.1 NZ_CP043947:58378-58659 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T139605 NZ_CP058748:3632124-3632666 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT139605 WP_000079941.1 NZ_CP043947:58112-58381 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT139605 NZ_CP058748:3631829-3632140 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References