Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1288847..1289487 Replicon chromosome
Accession NZ_CP043939
Organism Paucilactobacillus nenjiangensis strain SH-Y15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F0161_RS06535 Protein ID WP_150204087.1
Coordinates 1288847..1289032 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F0161_RS06540 Protein ID WP_150204088.1
Coordinates 1289053..1289487 (+) Length 145 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0161_RS06510 1283894..1284976 - 1083 WP_150204084.1 PTS fructose transporter subunit EIIC -
F0161_RS06515 1284988..1285443 - 456 WP_137601099.1 fructose PTS transporter subunit IIA -
F0161_RS06520 1285599..1287671 + 2073 WP_150204085.1 PRD domain-containing protein -
F0161_RS06525 1287758..1288075 + 318 WP_137601101.1 MazG-like family protein -
F0161_RS06530 1288228..1288677 + 450 WP_150204086.1 type II toxin-antitoxin system HicB family antitoxin -
F0161_RS06535 1288847..1289032 + 186 WP_150204087.1 type II toxin-antitoxin system HicA family toxin Toxin
F0161_RS06540 1289053..1289487 + 435 WP_150204088.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F0161_RS06545 1289536..1290663 - 1128 WP_190318842.1 glycerate kinase -
F0161_RS06550 1290844..1291134 + 291 WP_150204090.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F0161_RS06555 1291127..1291393 + 267 WP_137601150.1 Txe/YoeB family addiction module toxin -
F0161_RS06560 1291529..1291867 - 339 WP_137601107.1 type II toxin-antitoxin system PemK/MazF family toxin -
F0161_RS06565 1291898..1292161 - 264 WP_150204091.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
F0161_RS06570 1292433..1293095 - 663 WP_170175887.1 DUF3800 domain-containing protein -
F0161_RS06575 1293168..1293839 - 672 WP_150204092.1 hypothetical protein -
F0161_RS06580 1294016..1294333 + 318 WP_150204660.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1285599..1340848 55249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-59)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 62 a.a.        Molecular weight: 6964.34 Da        Isoelectric Point: 11.7889

>T139537 WP_150204087.1 NZ_CP043939:1288847-1289032 [Paucilactobacillus nenjiangensis]
MPMTQRQMVKLLHRHGWKKVIGGKGSHIKMSKVGHRPITVPHGELNRITQDAIFKEANLII

Download         Length: 186 bp

>T139537 NZ_CP058725:241991-242245 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16192.45 Da        Isoelectric Point: 4.5622

>AT139537 WP_150204088.1 NZ_CP043939:1289053-1289487 [Paucilactobacillus nenjiangensis]
MLVSYPALFYFLENEPVNYYIYFPDIKSTGTQGTDIPDAMSMASDWLGIMLADDITNERPVANPSNINDLSLKTDAPQQT
LNFDPTRSFISMVNVDLTNYLTANHPIKKTLTIPQWADKIGQKLNINFSQTLTDAILAKNIKTK

Download         Length: 435 bp

>AT139537 NZ_CP058725:241743-241994 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References