Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1288847..1289487 | Replicon | chromosome |
Accession | NZ_CP043939 | ||
Organism | Paucilactobacillus nenjiangensis strain SH-Y15 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | F0161_RS06535 | Protein ID | WP_150204087.1 |
Coordinates | 1288847..1289032 (+) | Length | 62 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | F0161_RS06540 | Protein ID | WP_150204088.1 |
Coordinates | 1289053..1289487 (+) | Length | 145 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F0161_RS06510 | 1283894..1284976 | - | 1083 | WP_150204084.1 | PTS fructose transporter subunit EIIC | - |
F0161_RS06515 | 1284988..1285443 | - | 456 | WP_137601099.1 | fructose PTS transporter subunit IIA | - |
F0161_RS06520 | 1285599..1287671 | + | 2073 | WP_150204085.1 | PRD domain-containing protein | - |
F0161_RS06525 | 1287758..1288075 | + | 318 | WP_137601101.1 | MazG-like family protein | - |
F0161_RS06530 | 1288228..1288677 | + | 450 | WP_150204086.1 | type II toxin-antitoxin system HicB family antitoxin | - |
F0161_RS06535 | 1288847..1289032 | + | 186 | WP_150204087.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
F0161_RS06540 | 1289053..1289487 | + | 435 | WP_150204088.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
F0161_RS06545 | 1289536..1290663 | - | 1128 | WP_190318842.1 | glycerate kinase | - |
F0161_RS06550 | 1290844..1291134 | + | 291 | WP_150204090.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
F0161_RS06555 | 1291127..1291393 | + | 267 | WP_137601150.1 | Txe/YoeB family addiction module toxin | - |
F0161_RS06560 | 1291529..1291867 | - | 339 | WP_137601107.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
F0161_RS06565 | 1291898..1292161 | - | 264 | WP_150204091.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
F0161_RS06570 | 1292433..1293095 | - | 663 | WP_170175887.1 | DUF3800 domain-containing protein | - |
F0161_RS06575 | 1293168..1293839 | - | 672 | WP_150204092.1 | hypothetical protein | - |
F0161_RS06580 | 1294016..1294333 | + | 318 | WP_150204660.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1285599..1340848 | 55249 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6964.34 Da Isoelectric Point: 11.7889
>T139537 WP_150204087.1 NZ_CP043939:1288847-1289032 [Paucilactobacillus nenjiangensis]
MPMTQRQMVKLLHRHGWKKVIGGKGSHIKMSKVGHRPITVPHGELNRITQDAIFKEANLII
MPMTQRQMVKLLHRHGWKKVIGGKGSHIKMSKVGHRPITVPHGELNRITQDAIFKEANLII
Download Length: 186 bp
>T139537 NZ_CP058725:241991-242245 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 145 a.a. Molecular weight: 16192.45 Da Isoelectric Point: 4.5622
>AT139537 WP_150204088.1 NZ_CP043939:1289053-1289487 [Paucilactobacillus nenjiangensis]
MLVSYPALFYFLENEPVNYYIYFPDIKSTGTQGTDIPDAMSMASDWLGIMLADDITNERPVANPSNINDLSLKTDAPQQT
LNFDPTRSFISMVNVDLTNYLTANHPIKKTLTIPQWADKIGQKLNINFSQTLTDAILAKNIKTK
MLVSYPALFYFLENEPVNYYIYFPDIKSTGTQGTDIPDAMSMASDWLGIMLADDITNERPVANPSNINDLSLKTDAPQQT
LNFDPTRSFISMVNVDLTNYLTANHPIKKTLTIPQWADKIGQKLNINFSQTLTDAILAKNIKTK
Download Length: 435 bp
>AT139537 NZ_CP058725:241743-241994 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|
Antitoxin
Source | ID | Structure |
---|