Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4628408..4629206 Replicon chromosome
Accession NZ_CP043937
Organism Escherichia coli strain RM14516

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FS841_RS22115 Protein ID WP_000854903.1
Coordinates 4628408..4628785 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FS841_RS22120 Protein ID WP_001280956.1
Coordinates 4628832..4629206 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS841_RS22095 (4624438) 4624438..4625976 - 1539 WP_001187199.1 lysine decarboxylation/transport transcriptional activator CadC -
FS841_RS22100 (4626787) 4626787..4627629 - 843 WP_050877246.1 DUF4942 domain-containing protein -
FS841_RS22105 (4627714) 4627714..4627911 - 198 WP_000839249.1 DUF957 domain-containing protein -
FS841_RS22110 (4627923) 4627923..4628411 - 489 WP_000779172.1 DUF5983 family protein -
FS841_RS22115 (4628408) 4628408..4628785 - 378 WP_000854903.1 TA system toxin CbtA family protein Toxin
FS841_RS22120 (4628832) 4628832..4629206 - 375 WP_001280956.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FS841_RS22125 (4629369) 4629369..4629590 - 222 WP_000692313.1 DUF987 domain-containing protein -
FS841_RS22130 (4629659) 4629659..4630135 - 477 WP_050876996.1 RadC family protein -
FS841_RS22135 (4630151) 4630151..4630636 - 486 WP_000849591.1 antirestriction protein -
FS841_RS22140 (4630691) 4630691..4631509 - 819 WP_096857390.1 DUF932 domain-containing protein -
FS841_RS22145 (4631599) 4631599..4631832 - 234 WP_001117559.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14338.30 Da        Isoelectric Point: 6.8528

>T139534 WP_000854903.1 NZ_CP043937:c4628785-4628408 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATDLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T139534 NZ_CP058719:c3881763-3881512 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATAGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13706.46 Da        Isoelectric Point: 6.4757

>AT139534 WP_001280956.1 NZ_CP043937:c4629206-4628832 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS

Download         Length: 375 bp

>AT139534 NZ_CP058719:c3881515-3881261 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References