Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 112812..113455 Replicon plasmid pSCKLB555-2
Accession NZ_CP043934
Organism Klebsiella pneumoniae strain 555

Toxin (Protein)


Gene name vagD Uniprot ID A0A155IU92
Locus tag F2X40_RS28000 Protein ID WP_000754567.1
Coordinates 112812..113228 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag F2X40_RS28005 Protein ID WP_001261275.1
Coordinates 113225..113455 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F2X40_RS27980 107863..108432 + 570 WP_064160296.1 type 1 fimbrial protein -
F2X40_RS27985 108491..109186 + 696 WP_064160295.1 molecular chaperone -
F2X40_RS27990 109198..111591 + 2394 WP_064163930.1 fimbrial biogenesis outer membrane usher protein -
F2X40_RS27995 111612..112631 + 1020 WP_064160291.1 type 1 fimbrial protein -
F2X40_RS28000 112812..113228 - 417 WP_000754567.1 type II toxin-antitoxin system VapC family toxin Toxin
F2X40_RS28005 113225..113455 - 231 WP_001261275.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F2X40_RS28015 113708..116284 - 2577 WP_017901322.1 EstP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..172565 172565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15108.61 Da        Isoelectric Point: 8.5403

>T139496 WP_000754567.1 NZ_CP043934:c113228-112812 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

>T139496 NZ_CP058714:2233647-2233754 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT139496 WP_001261275.1 NZ_CP043934:c113455-113225 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp

>AT139496 NZ_CP058714:c2233590-2233535 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155IU92

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References