Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3937477..3938134 Replicon chromosome
Accession NZ_CP043932
Organism Klebsiella pneumoniae strain 555

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag F2X40_RS19395 Protein ID WP_002916310.1
Coordinates 3937724..3938134 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag F2X40_RS19390 Protein ID WP_002916312.1
Coordinates 3937477..3937743 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F2X40_RS19365 3932633..3934066 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
F2X40_RS19370 3934185..3934913 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
F2X40_RS19375 3934963..3935274 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
F2X40_RS19380 3935438..3936097 + 660 WP_002916317.1 hemolysin III family protein -
F2X40_RS19385 3936248..3937231 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
F2X40_RS19390 3937477..3937743 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
F2X40_RS19395 3937724..3938134 + 411 WP_002916310.1 protein YgfX Toxin
F2X40_RS19400 3938141..3938662 - 522 WP_004144730.1 flavodoxin FldB -
F2X40_RS19405 3938763..3939659 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
F2X40_RS19410 3939682..3940395 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F2X40_RS19415 3940401..3942134 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T139484 WP_002916310.1 NZ_CP043932:3937724-3938134 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T139484 NZ_CP058711:97080-97361 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT139484 WP_002916312.1 NZ_CP043932:3937477-3937743 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT139484 NZ_CP058711:96839-97090 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References