Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2549694..2550210 Replicon chromosome
Accession NZ_CP043932
Organism Klebsiella pneumoniae strain 555

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag F2X40_RS12535 Protein ID WP_004178374.1
Coordinates 2549694..2549978 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag F2X40_RS12540 Protein ID WP_002886901.1
Coordinates 2549968..2550210 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F2X40_RS12515 2545089..2545397 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
F2X40_RS30325 2545482..2545655 + 174 WP_032412860.1 hypothetical protein -
F2X40_RS12520 2545658..2546401 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
F2X40_RS12525 2546758..2548896 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
F2X40_RS12530 2549226..2549690 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
F2X40_RS12535 2549694..2549978 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F2X40_RS12540 2549968..2550210 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F2X40_RS12545 2550288..2552198 - 1911 WP_004152270.1 BglG family transcription antiterminator -
F2X40_RS12550 2552221..2553375 - 1155 WP_002886900.1 lactonase family protein -
F2X40_RS12555 2553442..2554182 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T139480 WP_004178374.1 NZ_CP043932:c2549978-2549694 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T139480 NZ_CP043932:c2549978-2549694 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT139480 WP_002886901.1 NZ_CP043932:c2550210-2549968 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT139480 NZ_CP043932:c2550210-2549968 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References