Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1838948..1839567 Replicon chromosome
Accession NZ_CP043932
Organism Klebsiella pneumoniae strain 555

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag F2X40_RS09190 Protein ID WP_002892050.1
Coordinates 1839349..1839567 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag F2X40_RS09185 Protein ID WP_002892066.1
Coordinates 1838948..1839322 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F2X40_RS09175 1834100..1835293 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
F2X40_RS09180 1835316..1838462 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
F2X40_RS09185 1838948..1839322 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
F2X40_RS09190 1839349..1839567 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
F2X40_RS09195 1839730..1840296 + 567 WP_002892030.1 maltose O-acetyltransferase -
F2X40_RS30260 1840268..1840408 - 141 WP_004147370.1 hypothetical protein -
F2X40_RS09200 1840429..1840899 + 471 WP_002892026.1 YlaC family protein -
F2X40_RS09205 1840874..1842325 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
F2X40_RS09210 1842426..1843124 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
F2X40_RS09215 1843121..1843261 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
F2X40_RS09220 1843261..1843524 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T139478 WP_002892050.1 NZ_CP043932:1839349-1839567 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T139478 NZ_CP058709:3061838-3061945 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT139478 WP_002892066.1 NZ_CP043932:1838948-1839322 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT139478 NZ_CP058709:c3061790-3061724 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References