Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 805091..805680 Replicon chromosome
Accession NZ_CP043929
Organism Methylomonas rhizoryzae strain GJ1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F1E05_RS03855 Protein ID WP_150046903.1
Coordinates 805091..805273 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F1E05_RS03860 Protein ID WP_150046905.1
Coordinates 805270..805680 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1E05_RS03825 800558..801103 + 546 WP_150046891.1 peroxidase-related enzyme -
F1E05_RS03830 801252..802538 + 1287 WP_150046893.1 pyridoxamine 5'-phosphate oxidase family protein -
F1E05_RS03835 802554..803159 + 606 WP_150046895.1 glutathione S-transferase -
F1E05_RS03840 803191..803664 + 474 WP_150046897.1 nuclear transport factor 2 family protein -
F1E05_RS03845 804329..804562 + 234 WP_150046899.1 antitoxin -
F1E05_RS03850 804567..804968 + 402 WP_150046901.1 type II toxin-antitoxin system VapC family toxin -
F1E05_RS03855 805091..805273 + 183 WP_150046903.1 type II toxin-antitoxin system HicA family toxin Toxin
F1E05_RS03860 805270..805680 + 411 WP_150046905.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1E05_RS03865 805928..806179 - 252 Protein_744 Txe/YoeB family addiction module toxin -
F1E05_RS03870 806449..807147 - 699 WP_150046907.1 hypothetical protein -
F1E05_RS03875 807269..808768 - 1500 WP_150046909.1 alkaline phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6621.68 Da        Isoelectric Point: 11.0776

>T139470 WP_150046903.1 NZ_CP043929:805091-805273 [Methylomonas rhizoryzae]
MNSAELIKQLQNDGWLLRGVKGSHHVFTHPSKPGHISVPHPRQDLGHGLVNKLLKQAGLK

Download         Length: 183 bp

>T139470 NZ_CP058709:581397-582719 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14600.47 Da        Isoelectric Point: 4.3019

>AT139470 WP_150046905.1 NZ_CP043929:805270-805680 [Methylomonas rhizoryzae]
MRYPIAIESGDETHAYGVVVPDLPGCFSAGDSLDEAIANAKDAIELWMETVIEDGQAIPEAAPIAKHQADPEFAGWIWAV
VEVDLSKLSGKAKRVNITLPERVLAAIDQAAARFGDTRSGLLAKAALEYVERHSEA

Download         Length: 411 bp

>AT139470 NZ_CP058709:581131-581397 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References