Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 101731..103229 Replicon chromosome
Accession NZ_CP043929
Organism Methylomonas rhizoryzae strain GJ1

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag F1E05_RS00470 Protein ID WP_150046045.1
Coordinates 101731..102993 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag F1E05_RS00475 Protein ID WP_150046046.1
Coordinates 102990..103229 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1E05_RS00440 96787..97158 + 372 WP_150046040.1 copper resistance protein CopC -
F1E05_RS00445 97183..97842 + 660 WP_150046041.1 hypothetical protein -
F1E05_RS00450 97842..98942 + 1101 WP_150051701.1 HupE/UreJ family protein -
F1E05_RS00455 99056..99790 + 735 WP_150046042.1 ribonuclease PH -
F1E05_RS00460 99803..100390 + 588 WP_150046043.1 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase -
F1E05_RS00465 100387..101478 + 1092 WP_150046044.1 aminoglycoside phosphotransferase family protein -
F1E05_RS00470 101731..102993 - 1263 WP_150046045.1 type II toxin-antitoxin system HipA family toxin Toxin
F1E05_RS00475 102990..103229 - 240 WP_150046046.1 helix-turn-helix transcriptional regulator Antitoxin
F1E05_RS00480 103475..103726 + 252 WP_197737395.1 hypothetical protein -
F1E05_RS00485 103932..104324 - 393 WP_150051703.1 helix-turn-helix domain-containing protein -
F1E05_RS00490 104832..105035 + 204 WP_150046047.1 hypothetical protein -
F1E05_RS00495 105051..105761 - 711 WP_197737396.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 46198.94 Da        Isoelectric Point: 6.8898

>T139468 WP_150046045.1 NZ_CP043929:c102993-101731 [Methylomonas rhizoryzae]
MSHLLAVYLFDRRVGELTLVEGRLQFSYDADWLQQSDAVPLSCSLPLQVEPFNDLQARPFFAGLLPEGKLRQLVARQFQV
SKQNDFALLDHIGGECAGAVSLLPPDGLPAVSNSASDIDWLSDDDLLAVLDELPQRPVLAGQDGLRLSLAGAQDKLPVVF
DGQRIGLPRNGTPSSHILKPAIAAVEDSVINEGFCLALAAAMQFQTAQSRICAIRDRSFLLVERYDRTQAANGQRLRLHQ
EDFCQALGVVPELKYQNEGGPGLEQCFDLVRRVTRPSAPQVLRLLDAVIFNALIGNHDAHAKNFSILYADKGAVLAPLYD
VLSTAVYSSLTPKMAMQLGGKYKFSEVQARHWERFAQAAGLSVAQTRKRILGLCQRLPVVARRLQTSANYQFAGNPVVEH
IVQLIEQRAALTVRRLTDNA

Download         Length: 1263 bp

>T139468 NZ_CP058709:191711-191814 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8411.80 Da        Isoelectric Point: 5.7353

>AT139468 WP_150046046.1 NZ_CP043929:c103229-102990 [Methylomonas rhizoryzae]
MINIHSTQQLGQALRNARKQLGLTQSELALAAGVGVRFIVDLEAGKPTVRLETVMRVIEALGGQVMLDGLPSVTGDEMP

Download         Length: 240 bp

>AT139468 NZ_CP058709:c191815-191581 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References