Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3494228..3495975 Replicon chromosome
Accession NZ_CP043925
Organism Proteus columbae strain T60

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag F1325_RS16360 Protein ID WP_160230719.1
Coordinates 3494228..3495601 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag F1325_RS16365 Protein ID WP_109374275.1
Coordinates 3495598..3495975 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1325_RS16345 3489906..3490874 - 969 WP_109374283.1 ABC transporter permease -
F1325_RS16350 3490874..3492457 - 1584 WP_109374278.1 ABC transporter substrate-binding protein -
F1325_RS16355 3492861..3493850 - 990 WP_109374277.1 glycosyltransferase -
F1325_RS16360 3494228..3495601 + 1374 WP_160230719.1 HipA domain-containing protein Toxin
F1325_RS16365 3495598..3495975 + 378 WP_109374275.1 helix-turn-helix domain-containing protein Antitoxin
F1325_RS16370 3496104..3496607 - 504 WP_109374274.1 hydrogenase maturation peptidase HycI -
F1325_RS16375 3496604..3497014 - 411 WP_109374273.1 formate hydrogenlyase maturation HycH family protein -
F1325_RS16380 3497007..3497789 - 783 WP_109374272.1 NADH-quinone oxidoreductase subunit B family protein -
F1325_RS16385 3497786..3498340 - 555 WP_075673442.1 hydrogenase 4 subunit H -
F1325_RS16390 3498352..3500085 - 1734 WP_109374271.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-415)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52801.32 Da        Isoelectric Point: 4.7336

>T139467 WP_160230719.1 NZ_CP043925:3494228-3495601 [Proteus columbae]
MEKVTLQAFLDQEWRDIAIINFPDHDRTLYANKYDITYPITELEYETNYSVDYLYQDDNHSVSINHPVALYFDDNGSPSW
LKFLDDIVPSGASRRYWVQYLDISNLTVEQQNYELLYHGTISPIGNLRVKESLPAPSNLNEHLVFTIDDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCSDNEEVWIDTYQDDISNHDKYYLVKFPRGKRSSIDCDILRTEYHFYHELTAMGFN
TISIEGMRLEEGNNYPSLWLPRFDIKRENHKVIRLAIESVYSILNKAPGTTLYHETVIRELIDKINQSNMVTQFDFQFDT
NDFIIEWVRRDLLNIIFGNSDNHGRNTSFIRNNNSIYLAPIYDFAPMKADPEGIARTTKWHSQSEMGGEYNFINIANSLS
DLIPQEQLLNALKETALQLITLKERLEVRGVPIQILTMPSFGFDFIPNKLERWGLLS

Download         Length: 1374 bp

>T139467 NZ_CP043925:3494228-3495601 [Proteus columbae]
ATGGAAAAAGTAACATTACAAGCATTTCTTGATCAAGAATGGAGAGATATTGCTATTATTAACTTTCCTGATCATGATCG
CACATTATATGCAAACAAGTATGATATTACCTATCCAATCACTGAATTAGAGTATGAAACAAATTATTCAGTGGATTACC
TGTATCAAGACGACAACCACTCTGTTTCTATTAATCATCCTGTTGCCCTTTATTTTGATGATAATGGCTCTCCAAGTTGG
CTTAAATTTTTAGATGATATTGTACCTAGTGGAGCCAGTCGGAGATATTGGGTTCAATATCTTGATATTTCGAATTTGAC
TGTAGAACAACAAAACTATGAATTACTTTATCATGGTACTATTTCACCTATTGGTAACTTACGTGTAAAAGAATCACTGC
CAGCCCCTTCTAACTTAAATGAACACCTTGTTTTTACTATTGATGATGTCAAAAATAGAGCCAGCGATTTTCTAGATTAC
GCACAACGTAAAGGCGCAGCCGCTGGTGGTGCAACAGGTGCCGGAGGCGAAGCTCCGAAATTGTTATTAAGATGCAGTGA
TAATGAAGAAGTTTGGATTGATACTTATCAAGATGATATATCTAACCATGATAAATATTACTTAGTTAAATTTCCGAGAG
GAAAACGTTCAAGTATAGATTGTGATATTTTAAGAACAGAATATCATTTTTATCATGAACTTACTGCAATGGGTTTCAAT
ACTATTTCTATTGAGGGTATGCGTCTAGAAGAAGGAAATAATTACCCTTCTTTATGGCTTCCTCGTTTTGATATCAAAAG
AGAAAATCATAAAGTTATTCGTTTAGCTATAGAATCTGTCTATTCCATATTGAATAAAGCACCTGGCACAACTCTATATC
ATGAAACAGTGATCAGAGAATTAATTGATAAAATTAATCAAAGTAATATGGTCACCCAATTTGATTTTCAATTTGATACA
AACGATTTTATTATTGAATGGGTAAGGCGAGATTTATTGAATATCATTTTTGGTAATAGTGATAATCATGGTCGAAATAC
TTCTTTTATAAGAAACAATAACTCAATTTATCTTGCCCCTATCTATGACTTTGCACCTATGAAGGCTGATCCTGAAGGTA
TTGCTAGAACAACAAAATGGCATTCACAAAGTGAAATGGGAGGAGAGTATAATTTTATTAATATCGCAAATTCTTTATCT
GATTTAATACCACAAGAACAGTTACTTAACGCGCTAAAAGAAACCGCCTTACAACTCATTACGTTAAAAGAAAGATTAGA
GGTAAGAGGTGTGCCAATACAAATCCTCACAATGCCTTCATTTGGTTTTGATTTTATACCTAATAAGCTAGAACGCTGGG
GATTACTATCATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14088.47 Da        Isoelectric Point: 10.8241

>AT139467 WP_109374275.1 NZ_CP043925:3495598-3495975 [Proteus columbae]
MSNVKNKIQISKPPARVSKTRQSVATVDRKEVINQIMSQLLFGEISQGEALKILRIKILSLNQERYAKLINISRKTLSEI
ENDKGNYSADIINKAFKPFGLKIGLIPFSPHVLFSLLKEHSNNNA

Download         Length: 378 bp

>AT139467 NZ_CP058693:c4101002-4100805 [Streptomyces sp. Rer75]
ATGGCTGCCCTGAATCTACGCTTTACCGATGACGAGCTGGACGCCTTGCGCAAGCGCGCCGAGGCGGAAGGCCGGAGCAT
GCAGTCGTTCGCGCACGATGCGGTGATCGCGGCGATCAACGAGCACTCCCGGCTGTTCAACGAGGCCGCGGCCCATGTGC
TGAAGGTCAGCGAAGAGCTGAACCGGAGGCTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References