Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3388121..3389843 | Replicon | chromosome |
| Accession | NZ_CP043925 | ||
| Organism | Proteus columbae strain T60 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | F1325_RS15840 | Protein ID | WP_160230698.1 |
| Coordinates | 3388121..3389059 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A6I7DD21 |
| Locus tag | F1325_RS15845 | Protein ID | WP_028870246.1 |
| Coordinates | 3389052..3389843 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F1325_RS15820 | 3384062..3384574 | - | 513 | WP_004249367.1 | S26 family signal peptidase | - |
| F1325_RS15825 | 3384558..3384905 | - | 348 | WP_004249366.1 | hypothetical protein | - |
| F1325_RS15830 | 3384898..3387297 | - | 2400 | WP_024008831.1 | type IV secretion system protein TraC | - |
| F1325_RS15835 | 3387297..3387989 | - | 693 | WP_031500474.1 | DsbC family protein | - |
| F1325_RS15840 | 3388121..3389059 | - | 939 | WP_160230698.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| F1325_RS15845 | 3389052..3389843 | - | 792 | WP_028870246.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| F1325_RS15850 | 3390064..3390450 | - | 387 | WP_000180225.1 | hypothetical protein | - |
| F1325_RS15855 | 3390447..3391019 | - | 573 | WP_160230699.1 | type IV conjugative transfer system lipoprotein TraV | - |
| F1325_RS15860 | 3391094..3392383 | - | 1290 | WP_156734091.1 | TraB/VirB10 family protein | - |
| F1325_RS15865 | 3392386..3393282 | - | 897 | WP_108479663.1 | type-F conjugative transfer system secretin TraK | - |
| F1325_RS15870 | 3393266..3393892 | - | 627 | WP_000667167.1 | hypothetical protein | - |
| F1325_RS15875 | 3393889..3394170 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | sul2 / tet(X6) / aph(4)-Ia / aac(3)-IVa / aph(3')-Ia | - | 3351959..3439369 | 87410 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35533.85 Da Isoelectric Point: 5.1171
>T139466 WP_160230698.1 NZ_CP043925:c3389059-3388121 [Proteus columbae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAK
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAK
Download Length: 939 bp
>T139466 NZ_CP058692:c6403-6008 [Paracoccus pantotrophus]
ATGAGCGCTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGATGATGGCCCGAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAAGTCCTGAACGAGACGCTGGTCAACTGTCGCCGCAAGGCTGGCCTGAGTT
GGGAGGAAGCAGGGGCGTTTCTTGAGGGCGTGCGCGCCTTGTGTCCCGTCGAAGACCTGACCCTTCAGACCCACGACGTC
GGCCGCGCCTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCCATGATCGTGGCCAGCGCTTTGGTTGCAGGCTGCAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAACTTCGCATCATCAACCCCTTTACATGA
ATGAGCGCTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGATGATGGCCCGAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAAGTCCTGAACGAGACGCTGGTCAACTGTCGCCGCAAGGCTGGCCTGAGTT
GGGAGGAAGCAGGGGCGTTTCTTGAGGGCGTGCGCGCCTTGTGTCCCGTCGAAGACCTGACCCTTCAGACCCACGACGTC
GGCCGCGCCTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCCATGATCGTGGCCAGCGCTTTGGTTGCAGGCTGCAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAACTTCGCATCATCAACCCCTTTACATGA
Antitoxin
Download Length: 264 a.a. Molecular weight: 30085.43 Da Isoelectric Point: 9.5097
>AT139466 WP_028870246.1 NZ_CP043925:c3389843-3389052 [Proteus columbae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT139466 NZ_CP058692:c6620-6393 [Paracoccus pantotrophus]
ATGCAGGTCGCGAAATGGGGCAACTCGCTTGCCGTCCGCCTGCCCGTCGAGCTTGTTCGGGATCTTGGCCTCAAGGAAGG
CGATCAGATCGACCTGGTCAAGGACGACGGCAAGGTCAGAGTCCGTCGTCTGGCGCGCGCGGATGAGGTGCTGACGGGTC
TGCGCCGGTTCCGGGGCAAGCTGCCCGCTGCAGAGCGCCTGAGCCGCGACGCTGCGCATGAGCGCTGA
ATGCAGGTCGCGAAATGGGGCAACTCGCTTGCCGTCCGCCTGCCCGTCGAGCTTGTTCGGGATCTTGGCCTCAAGGAAGG
CGATCAGATCGACCTGGTCAAGGACGACGGCAAGGTCAGAGTCCGTCGTCTGGCGCGCGCGGATGAGGTGCTGACGGGTC
TGCGCCGGTTCCGGGGCAAGCTGCCCGCTGCAGAGCGCCTGAGCCGCGACGCTGCGCATGAGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|