Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 714623..715262 Replicon chromosome
Accession NZ_CP043925
Organism Proteus columbae strain T60

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F1325_RS03330 Protein ID WP_109371744.1
Coordinates 714623..715027 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F1325_RS03335 Protein ID WP_099074198.1
Coordinates 715020..715262 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1325_RS03300 709870..710319 + 450 WP_006535128.1 transcriptional regulator NrdR -
F1325_RS03305 710390..711544 + 1155 WP_167392468.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
F1325_RS03310 711758..712228 + 471 WP_160229986.1 6,7-dimethyl-8-ribityllumazine synthase -
F1325_RS03315 712257..712670 + 414 WP_006535124.1 transcription antitermination factor NusB -
F1325_RS03320 712774..713757 + 984 WP_160229987.1 thiamine-phosphate kinase -
F1325_RS03325 713847..714182 - 336 WP_109371746.1 phnA family protein -
F1325_RS03330 714623..715027 - 405 WP_109371744.1 type II toxin-antitoxin system VapC family toxin Toxin
F1325_RS03335 715020..715262 - 243 WP_099074198.1 antitoxin Antitoxin
F1325_RS03340 715380..716387 - 1008 WP_196564086.1 ribose operon transcriptional repressor RbsR -
F1325_RS03345 716392..717318 - 927 WP_160229988.1 ribokinase -
F1325_RS03350 717397..718287 - 891 WP_109371738.1 ribose ABC transporter substrate-binding protein RbsB -
F1325_RS03355 718330..719295 - 966 WP_069368591.1 ribose ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15288.51 Da        Isoelectric Point: 7.5228

>T139464 WP_109371744.1 NZ_CP043925:c715027-714623 [Proteus columbae]
MIKYLLDTNIVIFTIKRRPEFLLPKFNQHAEQLAISTITLAELIFGAEKSLNSAKNLATVNDFVSRLTVLSYDELAAFHY
GEIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTHH

Download         Length: 405 bp

>T139464 NZ_CP058690:1759645-1760034 [Paracoccus pantotrophus]
ATGCTCGACACCAATATCGTCTCGGATCTGCTGCGACATCCTGACGGCAGCGCGGCAAAGCGCATTGCCGAGGTCGGCCC
GGATGCGATCTGCGTGAGCATCATCACAGCCGCAGAGCTGCGATATGGGTGCGCCAGGAAAGGGTCTGCGAAACTCCTGG
CGCATGTCGAAGCGATACTGGAAAGTGTGCAGGTTCTGGCGCTTGATGTGCCTGCTGACGCGGAGTATGGCGGCATTCGT
GCCGAGCTTGAGGCCGCTGGCAAGCCCATTGGTCCGAACGATCTGTTGATCGCAGCTCATGCCTACGCCGCAGGCGCAAT
CCTCGTAACTGACAACACGGGCGAATTTTCCCGCGTTCGCGGCCTGCGGGTTGAAAACTGGATCAGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9378.43 Da        Isoelectric Point: 4.6028

>AT139464 WP_099074198.1 NZ_CP043925:c715262-715020 [Proteus columbae]
MIQHGKVFMSNRTQNVRLPAETRFPDDVKEVFVRVKGKERIITPIQNAWDSFFLSDQSVTDDFLSERPDQVTSERESFDD

Download         Length: 243 bp

>AT139464 NZ_CP058690:1759373-1759636 [Paracoccus pantotrophus]
ATGCCGCATCCGCAGCCGTATTCAGAGCCTCGTGAAGCCAAGCTCTTCCGTAACAACAAGAGCCAGGCCGTCCGCATTCC
CGCAGACTTCGAGATGCCGGGGGATCGGGTGAACATCTATCGTGATGGGAACCGGCTTATCATCGAGCCGGTGCGCCGCA
AGAACCTGCTTGAAGTGCTGGCCGGACTAGACCCGCTCGGGCCAGAGGATCAGTTTCCTGATGTGGACGAGACGCTTCTC
CCGGCCAAGGAAATCGACATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References