Detailed information of TA system TA139463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 460382..461232
• Replicon: chromosome
• Accession: NZ_CP043925
• Organism: Proteus columbae strain T60

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: F1325_RS19230
• Protein ID: WP_196564491.1
• Coordinates: 460382..460825 (-)
• Length: 148 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: F1325_RS02220
• Protein ID: WP_160229941.1
• Coordinates: 460822..461232 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1325_RS02190	456149..457762	-	1614	WP_109374304.1	sigma 54-interacting transcriptional regulator	-
F1325_RS02195	458167..458724	+	558	WP_109374305.1	electron transport protein HydN	-
F1325_RS02200	458797..459138	+	342	WP_109374306.1	hydrogenase maturation nickel metallochaperone HypA	-
F1325_RS02205	459147..459440	+	294	WP_160229939.1	hydrogenase maturation factor HybG	-
F1325_RS02210	459571..459885	+	315	WP_160229940.1	quaternary ammonium compound efflux SMR transporter SugE	-
F1325_RS19225	459913..460437	-	525	WP_196564497.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
F1325_RS19230	460382..460825	-	444	WP_196564491.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
F1325_RS02220	460822..461232	-	411	WP_160229941.1	S-adenosylhomocysteine hydrolase	Antitoxin
F1325_RS02225	461655..462865	+	1211	WP_160229872.1	IS3 family transposase	-
F1325_RS02230	462908..463267	-	360	WP_006535438.1	fumarate reductase subunit FrdD	-
F1325_RS02235	463282..463674	-	393	WP_088493866.1	fumarate reductase subunit FrdC	-
F1325_RS02240	463689..464426	-	738	WP_075672948.1	succinate dehydrogenase/fumarate reductase iron-sulfur subunit	-
F1325_RS02245	464419..466215	-	1797	WP_109374308.1	fumarate reductase (quinol) flavoprotein subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	424175..573848	149673
	-	flank	IS/Tn	-	-	461655..462062	407

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (32-111)

Antitoxin

• Protein of unknown function DUF6088 (6-130)

Sequences

Toxin

Protein

• Length: 148 a.a.
• Molecular weight: 16807.23 Da
• Isoelectric Point: 9.4657

>T139463 WP_196564491.1 NZ_CP043925:c460825-460382 [Proteus columbae]
MIKLKNQFLEVSDALALGNPAIPEKDYWVVALLAQLATLNFDTHQMVFSGGTALAKSHVRIFRMSEDVDIKLIPTDVFNS
FSRDKRKALLKEIEDILTLQSSHFSIEEKIVRDEYRYTLSNLVKPLFTSNHQTRVNRNHSSTPSRTS

Nucleotide

• Length: 444 bp

>T139463 NZ_CP058690:c1232629-1232342 [Paracoccus pantotrophus]
ATGAAGGCGTTGGCCTTCACCGTCGCGGCAACGGTCGATCTGGAGGATATCTGGGATTATACGGAAGGCGAATGGGGCCT
CGCGCAAGCCCGGCGCTATGTGCAGGAGCTGCGCGACACCTGCCATGCGCTGGCATCGGGTGAAAGGCGCGGCAGGTCGG
TTGACGTTCGGCCTGGCTATCTGAAGTGCCTGAGCGGATCGCATGTCATCTTCTTCCGGGATCTGGGCGATACGCTGGAA
ATCGTCCGCATCCTGCACGGCGCGCAGGACGCCGAGCGGCATTTGTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15308.60 Da
• Isoelectric Point: 10.8139

>AT139463 WP_160229941.1 NZ_CP043925:c461232-460822 [Proteus columbae]
MTAANQINQKLKRSRRYVFERKDFADIASYDQIGRALNQLIKQGNLMKIGYGLYTKARENSLTGRLMPTNPGGTDAILRE
VLKMKGVDFEIDALSLQSLSGNSTQIPSTVRYSWDPKQFNRKLVIGNRVLSAPNSK

Nucleotide

• Length: 411 bp

>AT139463 NZ_CP058690:c1232871-1232626 [Paracoccus pantotrophus]
ATGTCCCGCAACACTTCGGTTTCGCTCGGCGATCACTTCGTCAGCTTCATCGACGCGCAGGTGAAGGGCGGCCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCAGGGCTGCGGCTTCTGGAGGAGCACGAGACCAAGGTAAAGGCGTTGGAAGCCGCCC
TGATCGCCGGAGAGGAATCCGGCCGGGCGGAAGGCTTCGACCTCGATCAATTCATTGCCCGCAAGATGGCCGGTCGCAAC
GCATGA