Detailed information of TA system TA139461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3430254..3431890
• Replicon: chromosome
• Accession: NZ_CP043910
• Organism: Acinetobacter baumannii strain AB043

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: AT571_RS16410
• Protein ID: WP_000737056.1
• Coordinates: 3430559..3431890 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: AT571_RS16405
• Protein ID: WP_001101308.1
• Coordinates: 3430254..3430562 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT571_RS16375	3425818..3426336	-	519	WP_000651611.1	GNAT family N-acetyltransferase	-
AT571_RS16380	3426484..3426999	-	516	WP_000914805.1	hypothetical protein	-
AT571_RS16385	3427041..3428123	-	1083	WP_001095788.1	ImmA/IrrE family metallo-endopeptidase	-
AT571_RS16390	3428141..3428761	-	621	WP_000658761.1	hypothetical protein	-
AT571_RS16395	3428977..3429528	-	552	WP_049594830.1	TetR/AcrR family transcriptional regulator	-
AT571_RS16405	3430254..3430562	-	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
AT571_RS16410	3430559..3431890	-	1332	WP_000737056.1	type II toxin-antitoxin system HipA family toxin	Toxin
AT571_RS16415	3432186..3432626	+	441	WP_000193135.1	HD domain-containing protein	-
AT571_RS16420	3432661..3433305	-	645	WP_000817301.1	hypothetical protein	-
AT571_RS16425	3433317..3434288	-	972	WP_109104914.1	acid phosphatase	-
AT571_RS16430	3434415..3435575	-	1161	WP_001044492.1	hypothetical protein	-
AT571_RS16435	3435568..3436806	-	1239	WP_011859301.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T139461 WP_000737056.1 NZ_CP043910:c3431890-3430559 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T139461 NZ_CP058689:1508445-1508744 [Paracoccus pantotrophus]
ATGGCACTGGAAACCACGGCCTTTGACCCGGCCGAATACCTCGACAACGACGAGGCGATTGCAGGCTACCTGTCCGATGC
CCTGGAAACCGGGGACGGAGCGTTCATCGCGGATGCGCTGGGCGTGGTCGCGCGCGCCAAGGGCATGAAGCAGATCGCCG
AGGATGCCGGGCTGTCGCGCGAAAGCCTCTACCGCGCCTTGAGCGAGAAGGGTAATCCCGAGTTCAGCACCGTGCTGAAG
GTGGTAGCGGCGCTGGGTCTCCGGCTCTCGGCCACCCCTGCGCATCATCCGGCAGAGTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT139461 WP_001101308.1 NZ_CP043910:c3430562-3430254 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT139461 NZ_CP058689:1508146-1508442 [Paracoccus pantotrophus]
ATGATCGAGATCCGCCAGACAGACACCTTCCGGGAATGGCTGCTTTCCCTTCGCGATGCACGGGCCAAGCAGAAGATTGC
CAGCCGCATCCAGCGGTTGCGGTTCGGAAACCCCGGAGACGTGAAGCCGGTTGGCGCTGGTGTGAGCGAAATGCGCATCA
ACGAGGGGCCCGGCTATCGGGTCTATTTCGTTCAGCGCGGATCGGTGCTGGTCGTTCTTTTGTGCGGCGGCACTAAGAGG
CGCCAGCAGGCGGATATTGAACAAGCGAAGCGGCTTGCCGCAGAGATGGAGGGTTGA

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1