Detailed information of TA system TA139460

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 925455..926096
• Replicon: chromosome
• Accession: NZ_CP043910
• Organism: Acinetobacter baumannii strain AB043

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A1E3M967
• Locus tag: AT571_RS04275
• Protein ID: WP_009518132.1
• Coordinates: 925455..925844 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: AT571_RS04280
• Protein ID: WP_011860336.1
• Coordinates: 925851..926096 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT571_RS04260	920572..922767	-	2196	WP_001158904.1	TRAP transporter large permease subunit	-
AT571_RS04265	922955..923521	-	567	WP_000651535.1	rhombosortase	-
AT571_RS04270	923600..924685	-	1086	WP_000049106.1	hypothetical protein	-
AT571_RS04275	925455..925844	-	390	WP_009518132.1	hypothetical protein	Toxin
AT571_RS04280	925851..926096	-	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
AT571_RS04285	926296..927468	+	1173	WP_001190550.1	acyl-CoA dehydrogenase family protein	-
AT571_RS04290	927518..929008	-	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
AT571_RS04295	929190..929567	-	378	WP_001216380.1	50S ribosomal protein L17	-
AT571_RS04300	929586..930593	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15720.03 Da
• Isoelectric Point: 10.4623

>T139460 WP_009518132.1 NZ_CP043910:c925844-925455 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T139460 NZ_CP058689:1508146-1508442 [Paracoccus pantotrophus]
ATGATCGAGATCCGCCAGACAGACACCTTCCGGGAATGGCTGCTTTCCCTTCGCGATGCACGGGCCAAGCAGAAGATTGC
CAGCCGCATCCAGCGGTTGCGGTTCGGAAACCCCGGAGACGTGAAGCCGGTTGGCGCTGGTGTGAGCGAAATGCGCATCA
ACGAGGGGCCCGGCTATCGGGTCTATTTCGTTCAGCGCGGATCGGTGCTGGTCGTTCTTTTGTGCGGCGGCACTAAGAGG
CGCCAGCAGGCGGATATTGAACAAGCGAAGCGGCTTGCCGCAGAGATGGAGGGTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT139460 WP_011860336.1 NZ_CP043910:c926096-925851 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT139460 NZ_CP058689:1508445-1508744 [Paracoccus pantotrophus]
ATGGCACTGGAAACCACGGCCTTTGACCCGGCCGAATACCTCGACAACGACGAGGCGATTGCAGGCTACCTGTCCGATGC
CCTGGAAACCGGGGACGGAGCGTTCATCGCGGATGCGCTGGGCGTGGTCGCGCGCGCCAAGGGCATGAAGCAGATCGCCG
AGGATGCCGGGCTGTCGCGCGAAAGCCTCTACCGCGCCTTGAGCGAGAAGGGTAATCCCGAGTTCAGCACCGTGCTGAAG
GTGGTAGCGGCGCTGGGTCTCCGGCTCTCGGCCACCCCTGCGCATCATCCGGCAGAGTGA

Structures

Toxin

• AlphaFold DB: A0A1E3M967