Detailed information of TA system TA139459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1599861..1600993
• Replicon: chromosome
• Accession: NZ_CP043909
• Organism: Acinetobacter sp. C16S1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: F2A31_RS07550
• Protein ID: WP_150025866.1
• Coordinates: 1599861..1600625 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: F2A31_RS07555
• Protein ID: WP_150025867.1
• Coordinates: 1600622..1600993 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F2A31_RS07525	1595779..1596636	+	858	WP_150025861.1	3-deoxy-8-phosphooctulonate synthase	-
F2A31_RS07530	1596727..1598016	+	1290	WP_150025862.1	phosphopyruvate hydratase	-
F2A31_RS07535	1598146..1598511	+	366	WP_150025863.1	cell division protein FtsB	-
F2A31_RS07540	1598501..1599199	+	699	WP_150025864.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
F2A31_RS07545	1599333..1599809	+	477	WP_150025865.1	hypothetical protein	-
F2A31_RS07550	1599861..1600625	-	765	WP_150025866.1	RES family NAD+ phosphorylase	Toxin
F2A31_RS07555	1600622..1600993	-	372	WP_150025867.1	DUF2384 domain-containing protein	Antitoxin
F2A31_RS07560	1601205..1601615	+	411	WP_150025868.1	YeeE/YedE family protein	-
F2A31_RS07565	1601628..1602038	+	411	WP_150025869.1	YeeE/YedE family protein	-
F2A31_RS07570	1602056..1602928	+	873	WP_150025870.1	MBL fold metallo-hydrolase	-
F2A31_RS07575	1603097..1603795	+	699	WP_005080590.1	phosphoglycerate mutase family protein	-
F2A31_RS07580	1603937..1604197	+	261	WP_005080592.1	hypothetical protein	-
F2A31_RS07585	1604324..1604908	+	585	WP_150025871.1	uracil-DNA glycosylase family protein	-
F2A31_RS07590	1604905..1605393	-	489	WP_134252221.1	pyridoxamine 5'-phosphate oxidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (68-207)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (73-121)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29091.01 Da
• Isoelectric Point: 6.3325

>T139459 WP_150025866.1 NZ_CP043909:c1600625-1599861 [Acinetobacter sp. C16S1]
MTAIEQNLWQSCEGNKHVSPLSGTLYRLVESQEQIATRQLVDTLEEQALLEDMLELVKPPYPPKSEHLHYLLKTPFRYPP
LKWGSRFGRTFEPSIFYGGCSVNVTLAESAYYRFVFWHSMDGTPKKKTIRSEHTLFSVGYHCNKGLRLQSPPFDQYLDLI
AHPTNYSYAQQLGTAMRNEGIEIFEYPSARASDHAICVGLFTAEHFSQHSPLNREQWFCDIGADEVIFKAVEGSSIVRFE
LSQFLQQGIFPMPA

Nucleotide

• Length: 765 bp

>T139459 NZ_CP058685:18701-18883 [Escherichia coli]
ATGAAATCTGCTGACCTGTTGAAAGAACTGATAGCTGCTGGTTGTGAGTTGAAGCGGCATAAGGCGAGCAGCCACCAGAT
ATGGTGGTCGCCCATAACAGGAAAAACTTTTCCTGTGCCCCATCCGAAAAAAGACTTGCCACTGGGTACTGTCAGATCGA
TCAGAAAAATGGCGGGGATTTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13350.67 Da
• Isoelectric Point: 10.4005

>AT139459 WP_150025867.1 NZ_CP043909:c1600993-1600622 [Acinetobacter sp. C16S1]
MSALLKQPADKKVVLAKAVLNAAEQLDLKQIQLAAILGVHRTAISRLKNNPELDPASKQGELALLLIRLSRALYALTGGD
TDWMRHFMNTPNRVTGGIPVEQIESISGLVSVLQFVDAIRGKV

Nucleotide

• Length: 372 bp

>AT139459 NZ_CP058685:18908-19345 [Escherichia coli]
ATGTTTTTTTCTGTGGGTGTCGAAACACCGAAAGATGACCATACGGCATATGGTATAACCGTTCCGGCTTTTGATCGTTT
TGATTTTGGCTGTGTCTCTGCTGCCGATACTCAATCAGAAATTCCTGTGATGGCGCGAGAAGCGATATTGGCTATCGTGG
AAGAAATGGTTTTAAGTGGTTCTTATTCTGTTGATGATATTCATGATGACGGCTGTTTAACATATGCCGCAAATCAGGAC
TATAGTCACTGCGATAGCTGGTTTGTAATTGATGTTGATTTGTCTGAAATTGAAGGTAAACAACAACGTATTAATATTGC
GTTGCCTGATGTGTTGATTCGTCGTATTGATGGATTTGTCAGAGAAAGTGGCGGTGTTTACAGAGATCGTAGCCATTTTC
TTGCTCAGGCCGCGCGGCATGAGCTTTCATATAAATGA