Detailed information of TA system TA139456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 11987..12512
• Replicon: plasmid unnamed
• Accession: NZ_CP043905
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: F1727_RS00090
• Protein ID: WP_001159863.1
• Coordinates: 11987..12292 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: F1727_RS00095
• Protein ID: WP_000813641.1
• Coordinates: 12294..12512 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1727_RS00050	7366..7926	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
F1727_RS00055	8082..8369	+	288	WP_071530243.1	hypothetical protein	-
F1727_RS00060	8646..9131	-	486	WP_000905606.1	membrane protein	-
F1727_RS00065	9125..9634	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
F1727_RS00070	9638..10351	-	714	Protein_13	EAL domain-containing protein	-
F1727_RS00075	10360..11142	-	783	WP_000082169.1	site-specific integrase	-
F1727_RS00080	11177..11698	-	522	WP_000198608.1	hypothetical protein	-
F1727_RS00085	11695..11985	-	291	WP_001266176.1	hypothetical protein	-
F1727_RS00090	11987..12292	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
F1727_RS00095	12294..12512	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
F1727_RS00100	13188..13709	+	522	WP_010999942.1	hypothetical protein	-
F1727_RS00105	14193..14489	+	297	WP_001687482.1	hypothetical protein	-
F1727_RS00110	14983..15972	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
F1727_RS00115	16231..16675	-	445	Protein_22	site-specific integrase	-
F1727_RS00120	16844..17225	-	382	Protein_23	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93830	93830

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T139456 WP_001159863.1 NZ_CP043905:c12292-11987 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T139456 NZ_CP058683:82599-83015 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGCATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATAAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT139456 WP_000813641.1 NZ_CP043905:c12512-12294 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT139456 NZ_CP058683:82372-82602 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6