Detailed information of TA system TA139453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 240588..241159
• Replicon: plasmid pSX1_LC6
• Accession: NZ_CP043903
• Organism: Shewanella sp. LC6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FJD32_RS23625
• Protein ID: WP_140907296.1
• Coordinates: 240588..240899 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1Z3MW28
• Locus tag: FJD32_RS23630
• Protein ID: WP_011787805.1
• Coordinates: 240899..241159 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJD32_RS23615	236573..237448	-	876	WP_181317832.1	sel1 repeat family protein	-
FJD32_RS23620	237478..240564	-	3087	WP_205403063.1	Tn3 family transposase	-
FJD32_RS23625	240588..240899	-	312	WP_140907296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FJD32_RS23630	240899..241159	-	261	WP_011787805.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FJD32_RS23635	241424..242026	-	603	WP_181159891.1	hypothetical protein	-
FJD32_RS23640	242579..242794	+	216	WP_140418345.1	hypothetical protein	-
FJD32_RS23645	242897..243214	+	318	WP_176400020.1	hypothetical protein	-
FJD32_RS23650	243381..243575	+	195	WP_088212956.1	hypothetical protein	-
FJD32_RS23655	244378..245310	+	933	WP_140907768.1	P-type conjugative transfer ATPase TrbB	-
FJD32_RS23660	245321..245668	+	348	WP_081990880.1	TrbC/VirB2 family protein	-
FJD32_RS23665	245679..245972	+	294	WP_047532983.1	VirB3 family type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aadA2 / qacE / sul1	-	1..355688	355688

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-61)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11835.67 Da
• Isoelectric Point: 8.5341

>T139453 WP_140907296.1 NZ_CP043903:c240899-240588 [Shewanella sp. LC6]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTILLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAERETI

Nucleotide

• Length: 312 bp

>T139453 NZ_CP058682:c5059835-5059500 [Escherichia coli]
GTGAATTTGAACGGGGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGGTGCTGGTCGACCTGC
GCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGGGCGGAAATTTTGCCC
GTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTGAATCAGGTGCGGATG
ATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGCGTTATTACGCTTGCA
GGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9312.71 Da
• Isoelectric Point: 6.4546

>AT139453 WP_011787805.1 NZ_CP043903:c241159-240899 [Shewanella sp. LC6]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Nucleotide

• Length: 261 bp

>AT139453 NZ_CP058682:c5060093-5059842 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Z3MW28