139452

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 178601..179172 Replicon plasmid pSX1_LC6
Accession NZ_CP043903
Organism Shewanella sp. LC6

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag FJD32_RS23390 Protein ID WP_011638897.1
Coordinates 178861..179172 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag FJD32_RS23385 Protein ID WP_011638898.1
Coordinates 178601..178861 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJD32_RS23355 174014..174640 + 627 WP_075123237.1 hypothetical protein -
FJD32_RS23360 174644..175153 + 510 WP_181159865.1 hypothetical protein -
FJD32_RS23365 175233..176537 + 1305 WP_010793081.1 IS1380-like element ISPa33 family transposase -
FJD32_RS23370 176798..177031 + 234 WP_140907497.1 DUF2845 domain-containing protein -
FJD32_RS23375 177342..177656 - 315 WP_039920606.1 hypothetical protein -
FJD32_RS23380 177842..178369 - 528 Protein_176 primase C-terminal domain-containing protein -
FJD32_RS23385 178601..178861 + 261 WP_011638898.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FJD32_RS23390 178861..179172 + 312 WP_011638897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJD32_RS23395 179196..182276 + 3081 WP_205403062.1 Tn3 family transposase -
FJD32_RS23400 182799..183161 - 363 WP_140906642.1 DUF2511 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / qacE / sul1 - 1..355688 355688
- flank IS/Tn - - 175233..176537 1304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T139452 WP_011638897.1 NZ_CP043903:178861-179172 [Shewanella sp. LC6]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T139452 NZ_CP043903:178861-179172 [Shewanella sp. LC6]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACATATTTATCAGGACTTAGACAAACGATTCAGCTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCGTGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT139452 WP_011638898.1 NZ_CP043903:178601-178861 [Shewanella sp. LC6]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT139452 NZ_CP058682:c4958323-4957955 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A883CRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZVH1

References