Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 1674849..1675665 Replicon chromosome
Accession NZ_CP043902
Organism Shewanella sp. LC6

Toxin (Protein)


Gene name hepT Uniprot ID A0A252EQR5
Locus tag FJD32_RS07625 Protein ID WP_069455295.1
Coordinates 1674849..1675250 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A501X4H4
Locus tag FJD32_RS07630 Protein ID WP_069455294.1
Coordinates 1675243..1675665 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJD32_RS07595 1669951..1671159 - 1209 WP_001206290.1 IS4-like element IS10A family transposase -
FJD32_RS07600 1671198..1671644 - 447 WP_205403038.1 hypothetical protein -
FJD32_RS07605 1671748..1672347 - 600 WP_069455299.1 metallophosphoesterase -
FJD32_RS07610 1672356..1672769 - 414 WP_069455298.1 hypothetical protein -
FJD32_RS07615 1672766..1673068 - 303 WP_205403039.1 hypothetical protein -
FJD32_RS07620 1673624..1674655 + 1032 WP_069455296.1 dTDP-glucose 4,6-dehydratase -
FJD32_RS07625 1674849..1675250 - 402 WP_069455295.1 type II toxin-antitoxin system toxin Toxin
FJD32_RS07630 1675243..1675665 - 423 WP_069455294.1 type II toxin-antitoxin system antitoxin Antitoxin
FJD32_RS07635 1675772..1676539 - 768 WP_086904479.1 HutD family protein -
FJD32_RS07640 1676815..1677261 - 447 WP_181159904.1 copper resistance protein NlpE -
FJD32_RS07645 1677652..1679013 + 1362 WP_109277866.1 GAF domain-containing sensor histidine kinase -
FJD32_RS07650 1679157..1680047 + 891 WP_055646646.1 glucose-1-phosphate thymidylyltransferase RfbA -
FJD32_RS07655 1680034..1680576 + 543 WP_037428279.1 dTDP-4-dehydrorhamnose 3,5-epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(12-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(7-97)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15296.57 Da        Isoelectric Point: 6.3185

>T139450 WP_069455295.1 NZ_CP043902:c1675250-1674849 [Shewanella sp. LC6]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Download         Length: 402 bp

>T139450 NZ_CP058682:4569882-4570169 [Escherichia coli]
ATTAGGAATTTAAATCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAA
GGATATGAATAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACC
CGCTGCAAGGTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAA
CTTTTACGATTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15795.88 Da        Isoelectric Point: 5.1520

>AT139450 WP_069455294.1 NZ_CP043902:c1675665-1675243 [Shewanella sp. LC6]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE

Download         Length: 423 bp

>AT139450 NZ_CP058682:4569634-4569894 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A252EQR5

Antitoxin

Source ID Structure
AlphaFold DB A0A501X4H4

References