Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1644551..1645143 Replicon chromosome
Accession NZ_CP043902
Organism Shewanella sp. LC6

Toxin (Protein)


Gene name hicA Uniprot ID A0A252ENI2
Locus tag FJD32_RS07475 Protein ID WP_014610888.1
Coordinates 1644889..1645143 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A252ENK1
Locus tag FJD32_RS07470 Protein ID WP_014610929.1
Coordinates 1644551..1644892 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJD32_RS07440 1640100..1640345 + 246 WP_014610893.1 type II toxin-antitoxin system CcdA family antitoxin -
FJD32_RS07445 1640364..1641458 - 1095 WP_083243992.1 transposase -
FJD32_RS07450 1641505..1641909 + 405 WP_069453179.1 IS200/IS605 family transposase -
FJD32_RS07455 1642016..1642288 + 273 WP_069453183.1 CcdB family protein -
FJD32_RS07460 1642643..1644010 + 1368 WP_014610930.1 HipA domain-containing protein -
FJD32_RS07465 1644007..1644387 + 381 WP_086904820.1 helix-turn-helix domain-containing protein -
FJD32_RS07470 1644551..1644892 - 342 WP_014610929.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FJD32_RS07475 1644889..1645143 - 255 WP_014610888.1 type II toxin-antitoxin system HicA family toxin Toxin
FJD32_RS07480 1645355..1646504 + 1150 Protein_1443 IS3 family transposase -
FJD32_RS07485 1646535..1647087 + 553 Protein_1444 GDP-mannose 4,6-dehydratase -
FJD32_RS07490 1647159..1647335 + 177 WP_205403037.1 tyrosine-type recombinase/integrase -
FJD32_RS07495 1647413..1647577 - 165 WP_014610884.1 hypothetical protein -
FJD32_RS07500 1647599..1648324 - 726 WP_088585328.1 zeta toxin family protein -
FJD32_RS07505 1648398..1649564 - 1167 WP_069453175.1 DUF3596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9480.99 Da        Isoelectric Point: 10.1453

>T139449 WP_014610888.1 NZ_CP043902:c1645143-1644889 [Shewanella sp. LC6]
MNKKHLRTLTAIFARPVSGAIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVISIKKWLERN
GVKA

Download         Length: 255 bp

>T139449 NZ_CP058682:4355534-4356076 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12379.91 Da        Isoelectric Point: 4.3992

>AT139449 WP_014610929.1 NZ_CP043902:c1644892-1644551 [Shewanella sp. LC6]
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA

Download         Length: 342 bp

>AT139449 NZ_CP058682:4355239-4355550 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A252ENI2

Antitoxin

Source ID Structure
AlphaFold DB A0A252ENK1

References