Detailed information of TA system TA139449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1644551..1645143
• Replicon: chromosome
• Accession: NZ_CP043902
• Organism: Shewanella sp. LC6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A252ENI2
• Locus tag: FJD32_RS07475
• Protein ID: WP_014610888.1
• Coordinates: 1644889..1645143 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A252ENK1
• Locus tag: FJD32_RS07470
• Protein ID: WP_014610929.1
• Coordinates: 1644551..1644892 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJD32_RS07440	1640100..1640345	+	246	WP_014610893.1	type II toxin-antitoxin system CcdA family antitoxin	-
FJD32_RS07445	1640364..1641458	-	1095	WP_083243992.1	transposase	-
FJD32_RS07450	1641505..1641909	+	405	WP_069453179.1	IS200/IS605 family transposase	-
FJD32_RS07455	1642016..1642288	+	273	WP_069453183.1	CcdB family protein	-
FJD32_RS07460	1642643..1644010	+	1368	WP_014610930.1	HipA domain-containing protein	-
FJD32_RS07465	1644007..1644387	+	381	WP_086904820.1	helix-turn-helix domain-containing protein	-
FJD32_RS07470	1644551..1644892	-	342	WP_014610929.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FJD32_RS07475	1644889..1645143	-	255	WP_014610888.1	type II toxin-antitoxin system HicA family toxin	Toxin
FJD32_RS07480	1645355..1646504	+	1150	Protein_1443	IS3 family transposase	-
FJD32_RS07485	1646535..1647087	+	553	Protein_1444	GDP-mannose 4,6-dehydratase	-
FJD32_RS07490	1647159..1647335	+	177	WP_205403037.1	tyrosine-type recombinase/integrase	-
FJD32_RS07495	1647413..1647577	-	165	WP_014610884.1	hypothetical protein	-
FJD32_RS07500	1647599..1648324	-	726	WP_088585328.1	zeta toxin family protein	-
FJD32_RS07505	1648398..1649564	-	1167	WP_069453175.1	DUF3596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9480.99 Da
• Isoelectric Point: 10.1453

>T139449 WP_014610888.1 NZ_CP043902:c1645143-1644889 [Shewanella sp. LC6]
MNKKHLRTLTAIFARPVSGAIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVISIKKWLERN
GVKA

Nucleotide

• Length: 255 bp

>T139449 NZ_CP058682:4355534-4356076 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12379.91 Da
• Isoelectric Point: 4.3992

>AT139449 WP_014610929.1 NZ_CP043902:c1644892-1644551 [Shewanella sp. LC6]
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA

Nucleotide

• Length: 342 bp

>AT139449 NZ_CP058682:4355239-4355550 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Toxin

• AlphaFold DB: A0A252ENI2

Antitoxin

• AlphaFold DB: A0A252ENK1