Detailed information of TA system TA139447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 411467..412017
• Replicon: chromosome
• Accession: NZ_CP043902
• Organism: Shewanella sp. LC6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FJD32_RS01925
• Protein ID: WP_140906526.1
• Coordinates: 411467..411766 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: V1DMX4
• Locus tag: FJD32_RS01930
• Protein ID: WP_023266112.1
• Coordinates: 411775..412017 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJD32_RS01905	407281..408396	-	1116	WP_140916755.1	hypothetical protein	-
FJD32_RS01910	408991..410340	+	1350	WP_037429356.1	group II intron reverse transcriptase/maturase	-
FJD32_RS01915	410434..410775	-	342	WP_140906524.1	hypothetical protein	-
FJD32_RS01920	411225..411455	+	231	WP_140906525.1	hypothetical protein	-
FJD32_RS01925	411467..411766	-	300	WP_140906526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FJD32_RS01930	411775..412017	-	243	WP_023266112.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FJD32_RS01935	412192..412935	-	744	WP_140906527.1	hypothetical protein	-
FJD32_RS01940	412946..414208	-	1263	WP_140906528.1	beta-ketoacyl-ACP synthase	-
FJD32_RS01945	414209..414934	-	726	WP_037424987.1	3-ketoacyl-ACP reductase FabG2	-
FJD32_RS01950	415035..415577	-	543	WP_099457321.1	hotdog family protein	-
FJD32_RS01955	415583..416800	-	1218	WP_140906529.1	beta-ketoacyl-[acyl-carrier-protein] synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11451.19 Da
• Isoelectric Point: 9.6267

>T139447 WP_140906526.1 NZ_CP043902:c411766-411467 [Shewanella sp. LC6]
MNNKRYKLSRLAQAHLLKIKDYTLQHVSESQWQKYKESLISGLQMLADNPGLGRSCNDIYPNGFYFPIGKHTAYFTKEDD
FILIVALLGQPQLPQNHLK

Nucleotide

• Length: 300 bp

>T139447 NZ_CP058682:c3420889-3420515 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8954.13 Da
• Isoelectric Point: 4.7483

>AT139447 WP_023266112.1 NZ_CP043902:c412017-411775 [Shewanella sp. LC6]
MQTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIHDYEQLEAMKADYLKHCFNAAKEDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT139447 NZ_CP058682:c3421310-3420936 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: V1DMX4