139441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3222822..3223450 Replicon chromosome
Accession NZ_CP043891
Organism Leptospira interrogans serovar Icterohaemorrhagiae strain 898

Toxin (Protein)


Gene name vapC Uniprot ID Q8F7E4
Locus tag Lepto898_RS13145 Protein ID WP_000281042.1
Coordinates 3223052..3223450 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q72P17
Locus tag Lepto898_RS13140 Protein ID WP_001192484.1
Coordinates 3222822..3223052 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Lepto898_RS13110 3218423..3218632 - 210 WP_000041838.1 hypothetical protein -
Lepto898_RS13115 3218764..3219393 + 630 WP_001081629.1 helix-turn-helix domain-containing protein -
Lepto898_RS13120 3219600..3220523 + 924 WP_000680714.1 M28 family peptidase -
Lepto898_RS13125 3220782..3221471 + 690 WP_000590460.1 SH3 domain-containing protein -
Lepto898_RS13130 3221674..3222003 + 330 WP_000611884.1 hypothetical protein -
Lepto898_RS13135 3222000..3222530 + 531 WP_000129981.1 hypothetical protein -
Lepto898_RS13140 3222822..3223052 + 231 WP_001192484.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Lepto898_RS13145 3223052..3223450 + 399 WP_000281042.1 type II toxin-antitoxin system VapC family toxin Toxin
Lepto898_RS13150 3223548..3223850 + 303 WP_000479559.1 hypothetical protein -
Lepto898_RS13155 3223905..3225052 + 1148 WP_100225665.1 IS3-like element IS1500A family transposase -
Lepto898_RS13160 3225107..3225334 + 228 WP_000130601.1 hypothetical protein -
Lepto898_RS13165 3225477..3226553 + 1077 WP_001170562.1 hypothetical protein -
Lepto898_RS13170 3226554..3227012 + 459 WP_001239008.1 GNAT family N-acetyltransferase -
Lepto898_RS13175 3227229..3228089 - 861 WP_000682236.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15139.76 Da        Isoelectric Point: 9.6893

>T139441 WP_000281042.1 NZ_CP043891:3223052-3223450 [Leptospira interrogans serovar Icterohaemorrhagiae]
MYLLDTNICIFLIKKKNATLLENLKKKLNKDLFVSSLTVAELEFGIQKSEFKEKNKVALIEFLTIFNILSFSDKDAESYG
IIRADLERKGNVIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKALKIENWTQ

Download         Length: 399 bp

>T139441 NZ_CP058682:2476825-2476928 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8698.99 Da        Isoelectric Point: 9.8940

>AT139441 WP_001192484.1 NZ_CP043891:3222822-3223052 [Leptospira interrogans serovar Icterohaemorrhagiae]
MQTAKLFINGRSQAVRLPKEFQFTGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSDDFFKEGREQPKSDKREKL

Download         Length: 231 bp

>AT139441 NZ_CP058682:c2476929-2476695 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6HAN6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2D7U1

References