139440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1468389..1468944 Replicon chromosome
Accession NZ_CP043891
Organism Leptospira interrogans serovar Icterohaemorrhagiae strain 898

Toxin (Protein)


Gene name chpK Uniprot ID Q72T28
Locus tag Lepto898_RS05925 Protein ID WP_000617907.1
Coordinates 1468624..1468944 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag Lepto898_RS05920 Protein ID WP_000844758.1
Coordinates 1468389..1468637 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Lepto898_RS05905 1464041..1466023 + 1983 WP_000802798.1 GAF domain-containing protein -
Lepto898_RS05910 1466665..1467123 - 459 WP_000453263.1 hypothetical protein -
Lepto898_RS05915 1467277..1467573 + 297 WP_000477061.1 helix-turn-helix domain-containing protein -
Lepto898_RS05920 1468389..1468637 + 249 WP_000844758.1 ribbon-helix-helix domain-containing protein Antitoxin
Lepto898_RS05925 1468624..1468944 + 321 WP_000617907.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Lepto898_RS05930 1469944..1470936 - 993 WP_000041092.1 aldolase -
Lepto898_RS05935 1471076..1472011 - 936 WP_000004530.1 ornithine carbamoyltransferase -
Lepto898_RS05940 1472815..1473282 + 468 WP_000060053.1 hypothetical protein -
Lepto898_RS05945 1473279..1473683 + 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11644.43 Da        Isoelectric Point: 9.8447

>T139440 WP_000617907.1 NZ_CP043891:1468624-1468944 [Leptospira interrogans serovar Icterohaemorrhagiae]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGKVEIGL

Download         Length: 321 bp

>T139440 NZ_CP058682:c2339128-2339021 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT139440 WP_000844758.1 NZ_CP043891:1468389-1468637 [Leptospira interrogans serovar Icterohaemorrhagiae]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT139440 NZ_CP058682:2339175-2339241 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q72T28

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HD92

References