Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 3120..3685 Replicon plasmid p3
Accession NZ_CP043890
Organism Leptospira interrogans serovar Canicola strain 782

Toxin (Protein)


Gene name mazE Uniprot ID A0A0C5XAD8
Locus tag Lepto782_RS22015 Protein ID WP_000237066.1
Coordinates 3120..3443 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID A0A0F6H5X2
Locus tag Lepto782_RS22020 Protein ID WP_000648189.1
Coordinates 3437..3685 (-) Length 83 a.a.

Genomic Context

Lepto782_RS22005Lepto782_RS22035Lepto782_RS21995Lepto782_RS22000Lepto782_RS22010Lepto782_RS22015Lepto782_RS22020Lepto782_RS22025Lepto782_RS22030Lepto782_RS22040Lepto782_RS22045
Location: 2366..2743 (378 bp)
Type: Others
Protein ID: WP_000603456.1
Location: 6115..7413 (1299 bp)
Type: Others
Protein ID: WP_000558495.1
Location: 983..1436 (454 bp)
Type: Others
Protein ID: Protein_1
Location: 1612..1752 (141 bp)
Type: Others
Protein ID: WP_002077221.1
Location: 2827..2997 (171 bp)
Type: Others
Protein ID: WP_002077237.1
Location: 3120..3443 (324 bp)
Type: Toxin
Protein ID: WP_000237066.1
Location: 3437..3685 (249 bp)
Type: Antitoxin
Protein ID: WP_000648189.1
Location: 3990..4676 (687 bp)
Type: Others
Protein ID: WP_082271315.1
Location: 4649..4954 (306 bp)
Type: Others
Protein ID: WP_000844596.1
Location: 7781..8263 (483 bp)
Type: Others
Protein ID: WP_002092119.1
Location: 8260..8544 (285 bp)
Type: Others
Protein ID: WP_061234873.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Lepto782_RS21995983..1436-454Protein_1hypothetical protein-
Lepto782_RS220001612..1752-141WP_002077221.1hypothetical protein-
Lepto782_RS220052366..2743+378WP_000603456.1hypothetical protein-
Lepto782_RS220102827..2997-171WP_002077237.1hypothetical protein-
Lepto782_RS220153120..3443-324WP_000237066.1type II toxin-antitoxin system PemK/MazF family toxinToxin
Lepto782_RS220203437..3685-249WP_000648189.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
Lepto782_RS220253990..4676-687WP_082271315.1restriction endonuclease-
Lepto782_RS220304649..4954-306WP_000844596.1hypothetical protein-
Lepto782_RS220356115..7413+1299WP_000558495.1group II intron reverse transcriptase/maturase-
Lepto782_RS220407781..8263-483WP_002092119.1hypothetical protein-
Lepto782_RS220458260..8544-285WP_061234873.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..7705977059
-flankIS/Tn--1..849848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12168.59 Da        Isoelectric Point: 10.5161

>T139438 WP_000237066.1 NZ_CP043890:c3443-3120 [Leptospira interrogans serovar Canicola]
MVISQYEVYLINLDPTVGHEIKKSRPCAIISPNEMNKTIGTIIIAPMTTKSRSYPTRVELTFQGKKGWIVLDQIRAVDKT
RLVKKLGKIDPKTVNKMKLVIKEMLVD

Download         Length: 324 bp

>T139438 NZ_CP058682:c2338057-2337950 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9507.04 Da        Isoelectric Point: 5.1749

>AT139438 WP_000648189.1 NZ_CP043890:c3685-3437 [Leptospira interrogans serovar Canicola]
MKASVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKTMSSNKDDKLFIPDSIDLLDKDW
EW

Download         Length: 249 bp

>AT139438 NZ_CP058682:2338107-2338170 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0C5XAD8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6H5X2

References