Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3298323..3298951 Replicon chromosome
Accession NZ_CP043880
Organism Leptospira interrogans serovar Bataviae strain 1548

Toxin (Protein)


Gene name vapC Uniprot ID Q8F7E4
Locus tag Lepto1548_RS13770 Protein ID WP_000281042.1
Coordinates 3298553..3298951 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A868A7V8
Locus tag Lepto1548_RS13765 Protein ID WP_001192479.1
Coordinates 3298323..3298553 (+) Length 77 a.a.

Genomic Context

Lepto1548_RS13750Lepto1548_RS13755Lepto1548_RS13760Lepto1548_RS13765Lepto1548_RS13770Lepto1548_RS13775Lepto1548_RS13780Lepto1548_RS13785Lepto1548_RS13790Lepto1548_RS13745Lepto1548_RS13795Lepto1548_RS13800
Location: 3294820..3295509 (690 bp)
Type: Others
Protein ID: WP_000590461.1
Location: 3295781..3296083 (303 bp)
Type: Others
Protein ID: WP_001092687.1
Location: 3296129..3297967 (1839 bp)
Type: Others
Protein ID: WP_001015573.1
Location: 3298323..3298553 (231 bp)
Type: Antitoxin
Protein ID: WP_001192479.1
Location: 3298553..3298951 (399 bp)
Type: Toxin
Protein ID: WP_000281042.1
Location: 3299049..3299360 (312 bp)
Type: Others
Protein ID: WP_000479561.1
Location: 3299371..3299598 (228 bp)
Type: Others
Protein ID: WP_000130601.1
Location: 3299740..3300820 (1081 bp)
Type: Others
Protein ID: Protein_2721
Location: 3300821..3301279 (459 bp)
Type: Others
Protein ID: WP_001239009.1
Location: 3293621..3294670 (1050 bp)
Type: Others
Protein ID: WP_001257771.1
Location: 3301495..3302355 (861 bp)
Type: Others
Protein ID: WP_000682239.1
Location: 3302866..3303624 (759 bp)
Type: Others
Protein ID: WP_000636956.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Lepto1548_RS137453293621..3294670-1050WP_001257771.1hypothetical protein-
Lepto1548_RS137503294820..3295509+690WP_000590461.1SH3 domain-containing protein-
Lepto1548_RS137553295781..3296083+303WP_001092687.1hypothetical protein-
Lepto1548_RS137603296129..3297967+1839WP_001015573.1hypothetical protein-
Lepto1548_RS137653298323..3298553+231WP_001192479.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
Lepto1548_RS137703298553..3298951+399WP_000281042.1type II toxin-antitoxin system VapC family toxinToxin
Lepto1548_RS137753299049..3299360+312WP_000479561.1hypothetical protein-
Lepto1548_RS137803299371..3299598+228WP_000130601.1hypothetical protein-
Lepto1548_RS137853299740..3300820+1081Protein_2721hypothetical protein-
Lepto1548_RS137903300821..3301279+459WP_001239009.1GNAT family N-acetyltransferase-
Lepto1548_RS137953301495..3302355-861WP_000682239.1hypothetical protein-
Lepto1548_RS138003302866..3303624-759WP_000636956.1DUF1554 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15139.76 Da        Isoelectric Point: 9.6893

>T139433 WP_000281042.1 NZ_CP043880:3298553-3298951 [Leptospira interrogans serovar Bataviae]
MYLLDTNICIFLIKKKNATLLENLKKKLNKDLFVSSLTVAELEFGIQKSEFKEKNKVALIEFLTIFNILSFSDKDAESYG
IIRADLERKGNVIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKALKIENWTQ

Download         Length: 399 bp

>T139433 NZ_CP058682:1108119-1108430 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCATCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8741.03 Da        Isoelectric Point: 8.6588

>AT139433 WP_001192479.1 NZ_CP043880:3298323-3298553 [Leptospira interrogans serovar Bataviae]
MQTAKLFINGRSQAVRLPKEFQFAGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSDDFFKEEREQPKSDKREKL

Download         Length: 231 bp

>AT139433 NZ_CP058682:1108427-1108846 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGCGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F6HAN6

Antitoxin

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Source
ID
Structure
No matching records found

References