139432

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 2880648..2881224 Replicon chromosome
Accession NZ_CP043880
Organism Leptospira interrogans serovar Bataviae strain 1548

Toxin (Protein)


Gene name chpK Uniprot ID Q93MT8
Locus tag Lepto1548_RS12130 Protein ID WP_000617906.1
Coordinates 2880648..2880989 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag Lepto1548_RS12135 Protein ID WP_000844758.1
Coordinates 2880976..2881224 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Lepto1548_RS12110 2875895..2876299 - 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -
Lepto1548_RS12115 2876296..2876763 - 468 WP_000060053.1 hypothetical protein -
Lepto1548_RS12120 2877567..2878502 + 936 WP_000004530.1 ornithine carbamoyltransferase -
Lepto1548_RS12125 2878642..2879634 + 993 WP_000041092.1 aldolase -
Lepto1548_RS12130 2880648..2880989 - 342 WP_000617906.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Lepto1548_RS12135 2880976..2881224 - 249 WP_000844758.1 ribbon-helix-helix domain-containing protein Antitoxin
Lepto1548_RS12140 2882041..2882337 - 297 WP_000477061.1 helix-turn-helix domain-containing protein -
Lepto1548_RS12145 2882491..2882932 + 442 Protein_2397 hypothetical protein -
Lepto1548_RS12150 2883566..2885548 - 1983 WP_000802799.1 HD family phosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12372.25 Da        Isoelectric Point: 6.3272

>T139432 WP_000617906.1 NZ_CP043880:c2880989-2880648 [Leptospira interrogans serovar Bataviae]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T139432 NZ_CP043880:c2880989-2880648 [Leptospira interrogans serovar Bataviae]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGATTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTTTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT139432 WP_000844758.1 NZ_CP043880:c2881224-2880976 [Leptospira interrogans serovar Bataviae]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT139432 NZ_CP058682:1035489-1035737 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MS74

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HD92

References