Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1509864..1510440 Replicon chromosome
Accession NZ_CP043876
Organism Leptospira interrogans serovar Icterohaemorrhagiae strain Langkawi

Toxin (Protein)


Gene name chpK Uniprot ID Q93MT8
Locus tag LeptoLang_RS06240 Protein ID WP_000617906.1
Coordinates 1510099..1510440 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag LeptoLang_RS06235 Protein ID WP_000844758.1
Coordinates 1509864..1510112 (+) Length 83 a.a.

Genomic Context

LeptoLang_RS06220LeptoLang_RS06230LeptoLang_RS06235LeptoLang_RS06240LeptoLang_RS06255LeptoLang_RS06260LeptoLang_RS06225LeptoLang_RS06245LeptoLang_RS06250
Location: 1505515..1507497 (1983 bp)
Type: Others
Protein ID: WP_000836895.1
Location: 1508751..1509047 (297 bp)
Type: Others
Protein ID: WP_000477061.1
Location: 1509864..1510112 (249 bp)
Type: Antitoxin
Protein ID: WP_000844758.1
Location: 1510099..1510440 (342 bp)
Type: Toxin
Protein ID: WP_000617906.1
Location: 1514220..1514687 (468 bp)
Type: Others
Protein ID: WP_000060051.1
Location: 1514684..1515088 (405 bp)
Type: Others
Protein ID: WP_001974506.1
Location: 1508139..1508597 (459 bp)
Type: Others
Protein ID: WP_000453266.1
Location: 1511349..1512341 (993 bp)
Type: Others
Protein ID: WP_000041092.1
Location: 1512481..1513416 (936 bp)
Type: Others
Protein ID: WP_000004530.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LeptoLang_RS062201505515..1507497+1983WP_000836895.1HD family phosphohydrolase-
LeptoLang_RS062251508139..1508597-459WP_000453266.1hypothetical protein-
LeptoLang_RS062301508751..1509047+297WP_000477061.1helix-turn-helix domain-containing protein-
LeptoLang_RS062351509864..1510112+249WP_000844758.1ribbon-helix-helix domain-containing proteinAntitoxin
LeptoLang_RS062401510099..1510440+342WP_000617906.1type II toxin-antitoxin system PemK/MazF family toxinToxin
LeptoLang_RS062451511349..1512341-993WP_000041092.1aldolase-
LeptoLang_RS062501512481..1513416-936WP_000004530.1ornithine carbamoyltransferase-
LeptoLang_RS062551514220..1514687+468WP_000060051.1hypothetical protein-
LeptoLang_RS062601514684..1515088+405WP_001974506.1pyridoxamine 5'-phosphate oxidase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12372.25 Da        Isoelectric Point: 6.3272

>T139429 WP_000617906.1 NZ_CP043876:1510099-1510440 [Leptospira interrogans serovar Icterohaemorrhagiae]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T139429 NZ_CP058673:35879-36184 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGTGATGAAAGCTGGCGCATGATGACCTCCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAACGCCATTAACCTGATGTTTTGGGGAATATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT139429 WP_000844758.1 NZ_CP043876:1509864-1510112 [Leptospira interrogans serovar Icterohaemorrhagiae]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT139429 NZ_CP058673:35659-35877 [Salmonella enterica]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M4MS74

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HD92

References