Detailed information of TA system TA139426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1657518..1658203
• Replicon: chromosome
• Accession: NZ_CP043871
• Organism: Neisseria gonorrhoeae strain NG196

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: F0T10_RS08580
• Protein ID: WP_003689143.1
• Coordinates: 1658021..1658203 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: F0T10_RS08575
• Protein ID: WP_003691454.1
• Coordinates: 1657518..1657919 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0T10_RS08520	1652565..1652780	-	216	WP_003691538.1	hypothetical protein	-
F0T10_RS08525	1652832..1653323	-	492	WP_003691537.1	siphovirus Gp157 family protein	-
F0T10_RS08530	1653320..1653502	-	183	WP_003691535.1	hypothetical protein	-
F0T10_RS08535	1653642..1654328	-	687	WP_082278088.1	hypothetical protein	-
F0T10_RS08540	1654397..1654558	-	162	WP_003693867.1	hypothetical protein	-
F0T10_RS08545	1654555..1654830	-	276	WP_047918704.1	hypothetical protein	-
F0T10_RS08550	1654983..1655315	-	333	WP_003695500.1	hypothetical protein	-
F0T10_RS08555	1655456..1655743	-	288	WP_050157611.1	hypothetical protein	-
F0T10_RS08560	1655740..1656216	-	477	WP_002255718.1	hypothetical protein	-
F0T10_RS08565	1656249..1656449	-	201	WP_003692842.1	hypothetical protein	-
F0T10_RS08570	1656638..1657420	+	783	WP_003689146.1	hypothetical protein	-
F0T10_RS08575	1657518..1657919	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F0T10_RS08580	1658021..1658203	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
F0T10_RS08585	1658373..1659191	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
F0T10_RS08590	1659188..1659886	-	699	WP_003689139.1	hypothetical protein	-
F0T10_RS08595	1660125..1660835	-	711	WP_050161643.1	helix-turn-helix transcriptional regulator	-
F0T10_RS08600	1660951..1661139	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
F0T10_RS08605	1661219..1661374	+	156	WP_003689578.1	hypothetical protein	-
F0T10_RS08610	1661351..1661539	-	189	WP_003691445.1	hypothetical protein	-
F0T10_RS08615	1661712..1661939	+	228	WP_003698261.1	helix-turn-helix domain-containing protein	-
F0T10_RS08620	1662057..1663121	+	1065	WP_003689134.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1642336..1676596	34260

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T139426 WP_003689143.1 NZ_CP043871:c1658203-1658021 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T139426 NZ_CP058671:3745415-3745726 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAAACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT139426 WP_003691454.1 NZ_CP043871:c1657919-1657518 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT139426 NZ_CP058671:3745723-3746169 [Salmonella enterica]
ATGAGAACTCATCGCCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTACTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACATCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2