Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1657518..1658203 | Replicon | chromosome |
| Accession | NZ_CP043871 | ||
| Organism | Neisseria gonorrhoeae strain NG196 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | F0T10_RS08580 | Protein ID | WP_003689143.1 |
| Coordinates | 1658021..1658203 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | F0T10_RS08575 | Protein ID | WP_003691454.1 |
| Coordinates | 1657518..1657919 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F0T10_RS08520 | 1652565..1652780 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| F0T10_RS08525 | 1652832..1653323 | - | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| F0T10_RS08530 | 1653320..1653502 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| F0T10_RS08535 | 1653642..1654328 | - | 687 | WP_082278088.1 | hypothetical protein | - |
| F0T10_RS08540 | 1654397..1654558 | - | 162 | WP_003693867.1 | hypothetical protein | - |
| F0T10_RS08545 | 1654555..1654830 | - | 276 | WP_047918704.1 | hypothetical protein | - |
| F0T10_RS08550 | 1654983..1655315 | - | 333 | WP_003695500.1 | hypothetical protein | - |
| F0T10_RS08555 | 1655456..1655743 | - | 288 | WP_050157611.1 | hypothetical protein | - |
| F0T10_RS08560 | 1655740..1656216 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| F0T10_RS08565 | 1656249..1656449 | - | 201 | WP_003692842.1 | hypothetical protein | - |
| F0T10_RS08570 | 1656638..1657420 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| F0T10_RS08575 | 1657518..1657919 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| F0T10_RS08580 | 1658021..1658203 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| F0T10_RS08585 | 1658373..1659191 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| F0T10_RS08590 | 1659188..1659886 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| F0T10_RS08595 | 1660125..1660835 | - | 711 | WP_050161643.1 | helix-turn-helix transcriptional regulator | - |
| F0T10_RS08600 | 1660951..1661139 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| F0T10_RS08605 | 1661219..1661374 | + | 156 | WP_003689578.1 | hypothetical protein | - |
| F0T10_RS08610 | 1661351..1661539 | - | 189 | WP_003691445.1 | hypothetical protein | - |
| F0T10_RS08615 | 1661712..1661939 | + | 228 | WP_003698261.1 | helix-turn-helix domain-containing protein | - |
| F0T10_RS08620 | 1662057..1663121 | + | 1065 | WP_003689134.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1642336..1676596 | 34260 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T139426 WP_003689143.1 NZ_CP043871:c1658203-1658021 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T139426 NZ_CP058671:3745415-3745726 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAAACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAAACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT139426 WP_003691454.1 NZ_CP043871:c1657919-1657518 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT139426 NZ_CP058671:3745723-3746169 [Salmonella enterica]
ATGAGAACTCATCGCCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTACTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACATCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
ATGAGAACTCATCGCCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTACTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACATCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|