139425

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 946906..947561 Replicon chromosome
Accession NZ_CP043871
Organism Neisseria gonorrhoeae strain NG196

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag F0T10_RS04835 Protein ID WP_003691083.1
Coordinates 946906..947325 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag F0T10_RS04840 Protein ID WP_003688410.1
Coordinates 947325..947561 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0T10_RS04815 942140..943681 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
F0T10_RS04820 943829..944608 + 780 WP_003701284.1 (Fe-S)-binding protein -
F0T10_RS04825 944605..945306 + 702 WP_003688414.1 lactate utilization protein C -
F0T10_RS04830 945303..946757 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
F0T10_RS04835 946906..947325 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
F0T10_RS04840 947325..947561 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
F0T10_RS04845 947767..947964 - 198 WP_033910354.1 IS3 family transposase -
F0T10_RS04850 948009..948587 - 579 WP_003688041.1 IS3 family transposase -
F0T10_RS04855 948592..949020 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
F0T10_RS04860 949232..949618 + 387 Protein_961 IS110 family transposase -
F0T10_RS04865 950001..950891 - 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
F0T10_RS04870 950902..952068 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
F0T10_RS04875 952140..952427 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T139425 WP_003691083.1 NZ_CP043871:c947325-946906 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T139425 NZ_CP058671:c3744182-3743871 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT139425 WP_003688410.1 NZ_CP043871:c947561-947325 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT139425 NZ_CP058671:c3743870-3743580 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References