Detailed information of TA system TA139424

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1867303..1867853
• Replicon: chromosome
• Accession: NZ_CP043869
• Organism: Neptunomonas concharum strain JCM17730

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F0U83_RS08680
• Protein ID: WP_138987400.1
• Coordinates: 1867542..1867853 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: F0U83_RS08675
• Protein ID: WP_138987399.1
• Coordinates: 1867303..1867545 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0U83_RS08640	1862666..1863490	-	825	WP_138987466.1	hypothetical protein	-
F0U83_RS08645	1863607..1864185	-	579	WP_138987393.1	NAD(P)H-dependent oxidoreductase	-
F0U83_RS08650	1864585..1865052	-	468	WP_138987394.1	hypothetical protein	-
F0U83_RS08655	1865118..1865366	-	249	WP_138987395.1	LysR family transcriptional regulator	-
F0U83_RS08660	1865445..1866059	-	615	WP_138987396.1	DNA-3-methyladenine glycosylase I	-
F0U83_RS08665	1866070..1866360	-	291	WP_138987397.1	hypothetical protein	-
F0U83_RS08670	1866360..1866953	-	594	WP_138987398.1	TetR/AcrR family transcriptional regulator	-
F0U83_RS08675	1867303..1867545	+	243	WP_138987399.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
F0U83_RS08680	1867542..1867853	+	312	WP_138987400.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F0U83_RS17160	1867970..1868113	+	144	WP_211343651.1	hypothetical protein	-
F0U83_RS08690	1868531..1869091	-	561	WP_138987401.1	cytochrome c	-
F0U83_RS08695	1869183..1869479	-	297	WP_127696237.1	hypothetical protein	-
F0U83_RS08700	1869521..1870267	-	747	WP_211343655.1	copper resistance protein B	-
F0U83_RS08705	1870372..1872189	-	1818	WP_138987403.1	copper resistance system multicopper oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-71)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12082.80 Da
• Isoelectric Point: 9.5977

>T139424 WP_138987400.1 NZ_CP043869:1867542-1867853 [Neptunomonas concharum]
MTPFQLTNKAKSDLRDIALFTFRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHLIFYRQTGSQN
IEIIRILHKSMDVNPIFGAVTTA

Nucleotide

• Length: 312 bp

>T139424 NZ_CP058671:c3423989-3423498 [Salmonella enterica]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGATCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGAATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9056.01 Da
• Isoelectric Point: 4.2213

>AT139424 WP_138987399.1 NZ_CP043869:1867303-1867545 [Neptunomonas concharum]
MAKNTSITLGDHFDGFVTNQIQSGRYSSASEVIRSALRLLEIQETKMNTLRQLLVEGEESGITDYDLDSFINELDSEERK

Nucleotide

• Length: 243 bp

>AT139424 NZ_CP058671:c3424279-3423986 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA