Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1256165..1256793 Replicon chromosome
Accession NZ_CP043869
Organism Neptunomonas concharum strain JCM17730

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F0U83_RS05925 Protein ID WP_138988660.1
Coordinates 1256165..1256347 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F0U83_RS05930 Protein ID WP_138988661.1
Coordinates 1256389..1256793 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0U83_RS16950 1251988..1252824 + 837 WP_170221911.1 Rha family transcriptional regulator -
F0U83_RS05905 1252883..1253188 - 306 WP_138988657.1 hypothetical protein -
F0U83_RS05910 1253651..1253989 - 339 WP_138988658.1 hypothetical protein -
F0U83_RS05915 1254089..1254802 - 714 WP_138988659.1 hypothetical protein -
F0U83_RS05920 1255202..1255714 + 513 WP_211343706.1 glycoside hydrolase family protein -
F0U83_RS05925 1256165..1256347 + 183 WP_138988660.1 type II toxin-antitoxin system HicA family toxin Toxin
F0U83_RS05930 1256389..1256793 + 405 WP_138988661.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F0U83_RS05935 1256951..1257130 - 180 WP_138988662.1 hypothetical protein -
F0U83_RS05940 1257156..1257332 - 177 WP_138988732.1 GNAT family N-acetyltransferase -
F0U83_RS05945 1257329..1258387 - 1059 WP_138988663.1 hypothetical protein -
F0U83_RS05950 1258466..1260178 - 1713 WP_138988664.1 diguanylate cyclase -
F0U83_RS05955 1260159..1261163 - 1005 WP_138988665.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1234651..1256793 22142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-125)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6921.00 Da        Isoelectric Point: 10.3434

>T139420 WP_138988660.1 NZ_CP043869:1256165-1256347 [Neptunomonas concharum]
VNSRKLIKMIEEDGWYYVRTTGDHHHYKHPEKRGLVTVTHPVKDIPKGTVNSILKQAGLK

Download         Length: 183 bp

>T139420 NZ_CP058671:2781029-2781274 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14061.82 Da        Isoelectric Point: 4.3581

>AT139420 WP_138988661.1 NZ_CP043869:1256389-1256793 [Neptunomonas concharum]
MRYPVVVHHEDGSAYGVTVPDIPGCFSAGDTMDDALESVKEAIQGHLQLLAEDGEVAPVATSVEAHVSNEDYAGGVWALV
EVDVTPYLGKSEKVTVTIPSIVLRGIEGAVQSGKAKNRSAFLTDASIQLLGGRI

Download         Length: 405 bp

>AT139420 NZ_CP058671:c2781238-2780872 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACTGCGCCCCCCTCTCCCCG
GCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References