Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3231777..3232393 Replicon chromosome
Accession NZ_CP043853
Organism Enterobacter hormaechei strain EB_P6_L3_02.19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F1867_RS15750 Protein ID WP_077266491.1
Coordinates 3232022..3232393 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F1867_RS15745 Protein ID WP_058687116.1
Coordinates 3231777..3232019 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1867_RS15715 3226836..3227636 + 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -
F1867_RS15720 3227755..3228354 + 600 WP_003861947.1 glucose-1-phosphatase -
F1867_RS15725 3228348..3229229 + 882 WP_003861949.1 virulence factor BrkB family protein -
F1867_RS15730 3229226..3229663 + 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
F1867_RS15735 3229708..3230649 + 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
F1867_RS15740 3230658..3231578 - 921 WP_017382675.1 alpha/beta hydrolase -
F1867_RS15745 3231777..3232019 + 243 WP_058687116.1 ribbon-helix-helix domain-containing protein Antitoxin
F1867_RS15750 3232022..3232393 + 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
F1867_RS15755 3232433..3233362 - 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
F1867_RS15760 3233359..3233994 - 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
F1867_RS15765 3233991..3234893 - 903 WP_014072386.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T139412 WP_077266491.1 NZ_CP043853:3232022-3232393 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T139412 NZ_CP058670:1029769-1030068 [Chryseoglobus indicus]
ATGAAAGCTGAGACGGTGAGTCGCTTTGATGCGGCCGACTACCTACCGGACGTGGAAACGGCGGCGGCGTACCTGGAAGC
CGCGATCGAAGAAGCCGGAGACGACCCGGCTGTGATCGCTACGGCTCTTGGCGCCATCGCGCGTTCCGGCAACCTCAGCG
AGTTGTCACGTCGAACAGGGATAAGCCGCGAAGGTCTGTACAAGGCGCTCTCCGCCGAGGGCAATCCCAGCTTTGCGACG
ATCGTCAAGGTAGCTAGGGCTCTCGGGCTCTCCATCGAGTTCCACGCCAGCGCACCGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9474.74 Da        Isoelectric Point: 4.4076

>AT139412 WP_058687116.1 NZ_CP043853:3231777-3232019 [Enterobacter hormaechei]
MSVLAELDMGRIFIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT139412 NZ_CP058670:1029471-1029779 [Chryseoglobus indicus]
ATAGAGGTGAGAAAGACGGCCATCTTCGACCGGTGGTTGTCGAATGTCAAGGACATGCGCGCCGTCGCACGCATCCTGGT
GCGCATCGATCGACTCGCACAGGGGAACGCAGGCGACGCTCGATCGATAGGTTCAGGACTATGGGAACTGCGCATCGACT
GCGGGCCCGGGTACCGGGTCTACTACCTGCGACGCGGAAAGGCTCTCGTGCTTCTGTTGTGCGGCGGTGACAAGTCGACG
CAGTCGCGTGACATCGAGCGGGCGTACGAGTTGGCGAGCGAGTGGAGAGGGCGGCACCATGAAAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References