Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2070472..2071092 Replicon chromosome
Accession NZ_CP043853
Organism Enterobacter hormaechei strain EB_P6_L3_02.19

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag F1867_RS10205 Protein ID WP_015571250.1
Coordinates 2070874..2071092 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag F1867_RS10200 Protein ID WP_006809850.1
Coordinates 2070472..2070846 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1867_RS10190 2065598..2066791 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
F1867_RS10195 2066814..2069960 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
F1867_RS10200 2070472..2070846 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
F1867_RS10205 2070874..2071092 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
F1867_RS10210 2071301..2071852 + 552 WP_015571251.1 maltose O-acetyltransferase -
F1867_RS10215 2071969..2072436 + 468 WP_023296041.1 hypothetical protein -
F1867_RS10220 2072408..2073868 - 1461 WP_045911102.1 PLP-dependent aminotransferase family protein -
F1867_RS10225 2073970..2074680 + 711 WP_032670463.1 GNAT family N-acetyltransferase -
F1867_RS10230 2074677..2074817 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
F1867_RS10235 2074820..2075080 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T139411 WP_015571250.1 NZ_CP043853:2070874-2071092 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T139411 NZ_CP058670:1029471-1029779 [Chryseoglobus indicus]
ATAGAGGTGAGAAAGACGGCCATCTTCGACCGGTGGTTGTCGAATGTCAAGGACATGCGCGCCGTCGCACGCATCCTGGT
GCGCATCGATCGACTCGCACAGGGGAACGCAGGCGACGCTCGATCGATAGGTTCAGGACTATGGGAACTGCGCATCGACT
GCGGGCCCGGGTACCGGGTCTACTACCTGCGACGCGGAAAGGCTCTCGTGCTTCTGTTGTGCGGCGGTGACAAGTCGACG
CAGTCGCGTGACATCGAGCGGGCGTACGAGTTGGCGAGCGAGTGGAGAGGGCGGCACCATGAAAGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT139411 WP_006809850.1 NZ_CP043853:2070472-2070846 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT139411 NZ_CP058670:1029769-1030068 [Chryseoglobus indicus]
ATGAAAGCTGAGACGGTGAGTCGCTTTGATGCGGCCGACTACCTACCGGACGTGGAAACGGCGGCGGCGTACCTGGAAGC
CGCGATCGAAGAAGCCGGAGACGACCCGGCTGTGATCGCTACGGCTCTTGGCGCCATCGCGCGTTCCGGCAACCTCAGCG
AGTTGTCACGTCGAACAGGGATAAGCCGCGAAGGTCTGTACAAGGCGCTCTCCGCCGAGGGCAATCCCAGCTTTGCGACG
ATCGTCAAGGTAGCTAGGGCTCTCGGGCTCTCCATCGAGTTCCACGCCAGCGCACCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References