Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 789109..789848 Replicon chromosome
Accession NZ_CP043853
Organism Enterobacter hormaechei strain EB_P6_L3_02.19

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag F1867_RS03825 Protein ID WP_003857133.1
Coordinates 789363..789848 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag F1867_RS03820 Protein ID WP_003857131.1
Coordinates 789109..789375 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1867_RS03800 784591..785577 + 987 WP_017382341.1 DUF979 domain-containing protein -
F1867_RS03805 785587..786582 + 996 WP_015570513.1 DUF2891 domain-containing protein -
F1867_RS03810 786604..787986 - 1383 WP_045911739.1 MFS transporter -
F1867_RS03815 788116..789045 + 930 WP_045911831.1 LysR family transcriptional regulator -
F1867_RS03820 789109..789375 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
F1867_RS03825 789363..789848 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
F1867_RS03830 790043..791446 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
F1867_RS03835 791475..792107 - 633 WP_001567369.1 hypothetical protein -
F1867_RS03840 792182..793150 + 969 Protein_754 IS5-like element IS903B family transposase -
F1867_RS03845 793375..794667 - 1293 WP_023303742.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T139409 WP_003857133.1 NZ_CP043853:789363-789848 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T139409 NZ_CP058669:349765-350046 [Hyphobacterium sp. CCMP332]
ATGATCCAGAGCACGCGAGGTAAACGCGCCGCAAATGCCCTGAAAGGCATCTATGGAAAAGGGTTTCCCGGTGATCTGGT
GAAGCGGACGCGGGCGATGCTTTCGGCGCTGGATGCAGCTGTTGTGCTGGACGATCTGCGGTTTCCGCCAGGCAACCATC
TTGAGGAGCTCAAGGGTGACCGGGCCGGGCAGCACTCCGTCCGCATCAGTCGCAAATGGCGCATCTGCTTTGTCTGGACC
GCCAACGGTCCCGCCAATGTCGAGATCGTGGATTACCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT139409 WP_003857131.1 NZ_CP043853:789109-789375 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT139409 NZ_CP058669:350058-350348 [Hyphobacterium sp. CCMP332]
ATGAGCCTGCTTGAAGATCCGATGCATCCCGGCGAAGTGCTGAAAGAGCTCTATCTTGATCCGCTGGACATGGGGGCGAT
TGCCTTTGCGCGGCGGCTGGGTGTTCCGCGCACGCGGATCGAGCGGCTGATCAAGGGAACAACGGGTATAACGCCGGACA
CCGCTTTGCGCCTTGCGCGGGCGTTCAGCACCATACCGGCTTACTGGATGAATCTGCAGACCAATTACGACATGGCGATC
GCGCGTAAAAAGGTGGACGTCTCCTGGATCGAACCGCTCGGCGCAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References