Detailed information of TA system TA139375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 48902..49278
• Replicon: plasmid unnamed
• Accession: NZ_CP043851
• Organism: Escherichia coli ATCC 8739

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: F1719_RS00300
• Protein ID: WP_000969988.1
• Coordinates: 49096..49278 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: F1719_RS00295
• Protein ID: WP_001324224.1
• Coordinates: 48902..49099 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1719_RS00275	44162..44398	+	237	WP_001323890.1	colicin V immunity protein	-
F1719_RS00280	44376..44687	+	312	WP_001259758.1	colicin V	-
F1719_RS00285	44857..46971	-	2115	WP_001183604.1	peptidase domain-containing ABC transporter	-
F1719_RS00290	46946..48220	-	1275	WP_000489609.1	HlyD family secretion protein	-
F1719_RS00295	48902..49099	+	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
F1719_RS00300	49096..49278	+	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F1719_RS00305	49377..49685	+	309	WP_000377483.1	hypothetical protein	-
F1719_RS00310	50245..51279	+	1035	WP_001190234.1	3-deoxy-7-phosphoheptulonate synthase	-
F1719_RS00315	52134..53582	+	1449	Protein_62	siderophore salmochelin receptor IroN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	vat / iroN / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA	1..116228	116228

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T139375 WP_000969988.1 NZ_CP043851:49096-49278 [Escherichia coli ATCC 8739]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T139375 NZ_CP058661:132521-132817 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT139375 WP_001324224.1 NZ_CP043851:48902-49099 [Escherichia coli ATCC 8739]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT139375 NZ_CP058661:132819-133214 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• AlphaFold DB: A0A075MDK3