Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 112052..112567 Replicon chromosome
Accession NZ_CP043849
Organism Micrococcus luteus strain NCCP 15687

Toxin (Protein)


Gene name relE Uniprot ID A0A4Y1LR91
Locus tag F1717_RS00585 Protein ID WP_041103932.1
Coordinates 112313..112567 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag F1717_RS00580 Protein ID WP_036340860.1
Coordinates 112052..112312 (+) Length 87 a.a.

Genomic Context

F1717_RS00560F1717_RS00580F1717_RS00585F1717_RS00590F1717_RS00595F1717_RS00615F1717_RS00620F1717_RS00565F1717_RS00570F1717_RS00575F1717_RS00600F1717_RS00605F1717_RS00610
Location: 107981..108547 (567 bp)
Type: Others
Protein ID: WP_158184352.1
Location: 112052..112312 (261 bp)
Type: Antitoxin
Protein ID: WP_036340860.1
Location: 112313..112567 (255 bp)
Type: Toxin
Protein ID: WP_041103932.1
Location: 112569..113135 (567 bp)
Type: Others
Protein ID: WP_041103934.1
Location: 113328..113573 (246 bp)
Type: Others
Protein ID: WP_078025880.1
Location: 115931..116149 (219 bp)
Type: Others
Protein ID: Protein_123
Location: 116162..116641 (480 bp)
Type: Others
Protein ID: WP_036316396.1
Location: 108860..109276 (417 bp)
Type: Others
Protein ID: Protein_113
Location: 109278..110433 (1156 bp)
Type: Others
Protein ID: Protein_114
Location: 110463..111866 (1404 bp)
Type: Others
Protein ID: WP_155932746.1
Location: 113587..114369 (783 bp)
Type: Others
Protein ID: WP_158184353.1
Location: 114369..114911 (543 bp)
Type: Others
Protein ID: WP_036340843.1
Location: 114908..115633 (726 bp)
Type: Others
Protein ID: WP_152744175.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F1717_RS00560107981..108547+567WP_158184352.1hypothetical protein-
F1717_RS00565108860..109276-417Protein_113phosphatidylinositol kinase-
F1717_RS00570109278..110433-1156Protein_114glycerate kinase-
F1717_RS00575110463..111866-1404WP_155932746.1GntP family permease-
F1717_RS00580112052..112312+261WP_036340860.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
F1717_RS00585112313..112567+255WP_041103932.1Txe/YoeB family addiction module toxinToxin
F1717_RS00590112569..113135+567WP_041103934.1mismatch-specific DNA-glycosylase-
F1717_RS00595113328..113573+246WP_078025880.1hypothetical protein-
F1717_RS00600113587..114369-783WP_158184353.1SCO1664 family protein-
F1717_RS00605114369..114911-543WP_036340843.1DUF3090 domain-containing protein-
F1717_RS00610114908..115633-726WP_152744175.1MSMEG_4193 family putative phosphomutase-
F1717_RS00615115931..116149+219Protein_123hypothetical protein-
F1717_RS00620116162..116641+480WP_036316396.1NUDIX hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9996.33 Da        Isoelectric Point: 7.3149

>T139369 WP_041103932.1 NZ_CP043849:112313-112567 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T139369 NZ_CP058658:c82183-81977 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGGGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT139369 WP_036340860.1 NZ_CP043849:112052-112312 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT139369 NZ_CP058658:82170-82231 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4Y1LR91

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A229HG25

References