Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 112052..112567 Replicon chromosome
Accession NZ_CP043849
Organism Micrococcus luteus strain NCCP 15687

Toxin (Protein)


Gene name relE Uniprot ID A0A4Y1LR91
Locus tag F1717_RS00585 Protein ID WP_041103932.1
Coordinates 112313..112567 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag F1717_RS00580 Protein ID WP_036340860.1
Coordinates 112052..112312 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1717_RS00560 107981..108547 + 567 WP_158184352.1 hypothetical protein -
F1717_RS00565 108860..109276 - 417 Protein_113 phosphatidylinositol kinase -
F1717_RS00570 109278..110433 - 1156 Protein_114 glycerate kinase -
F1717_RS00575 110463..111866 - 1404 WP_155932746.1 GntP family permease -
F1717_RS00580 112052..112312 + 261 WP_036340860.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F1717_RS00585 112313..112567 + 255 WP_041103932.1 Txe/YoeB family addiction module toxin Toxin
F1717_RS00590 112569..113135 + 567 WP_041103934.1 mismatch-specific DNA-glycosylase -
F1717_RS00595 113328..113573 + 246 WP_078025880.1 hypothetical protein -
F1717_RS00600 113587..114369 - 783 WP_158184353.1 SCO1664 family protein -
F1717_RS00605 114369..114911 - 543 WP_036340843.1 DUF3090 domain-containing protein -
F1717_RS00610 114908..115633 - 726 WP_152744175.1 MSMEG_4193 family putative phosphomutase -
F1717_RS00615 115931..116149 + 219 Protein_123 hypothetical protein -
F1717_RS00620 116162..116641 + 480 WP_036316396.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9996.33 Da        Isoelectric Point: 7.3149

>T139369 WP_041103932.1 NZ_CP043849:112313-112567 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T139369 NZ_CP058658:c82183-81977 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGGGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT139369 WP_036340860.1 NZ_CP043849:112052-112312 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT139369 NZ_CP058658:82170-82231 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1LR91

Antitoxin

Source ID Structure
AlphaFold DB A0A229HG25

References