Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2356241..2356770 Replicon chromosome
Accession NZ_CP043847
Organism Staphylococcus epidermidis strain NCCP 16828

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag F1614_RS11365 Protein ID WP_001829891.1
Coordinates 2356408..2356770 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag F1614_RS11360 Protein ID WP_001829931.1
Coordinates 2356241..2356411 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1614_RS11335 2352065..2352544 + 480 WP_017464701.1 PH domain-containing protein -
F1614_RS11340 2352537..2354042 + 1506 WP_002474633.1 PH domain-containing protein -
F1614_RS11345 2354029..2354538 + 510 WP_001829888.1 PH domain-containing protein -
F1614_RS11350 2354586..2354939 + 354 WP_001829915.1 holo-ACP synthase -
F1614_RS11355 2355006..2356154 + 1149 WP_002494207.1 alanine racemase -
F1614_RS11360 2356241..2356411 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
F1614_RS11365 2356408..2356770 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F1614_RS11370 2357115..2358116 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
F1614_RS11375 2358216..2358542 + 327 WP_001829952.1 anti-sigma factor antagonist -
F1614_RS11380 2358544..2359023 + 480 WP_002474646.1 anti-sigma B factor RsbW -
F1614_RS11385 2358998..2359768 + 771 WP_002474636.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T139367 WP_001829891.1 NZ_CP043847:2356408-2356770 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T139367 NZ_CP058656:c4207051-4206878 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT139367 WP_001829931.1 NZ_CP043847:2356241-2356411 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT139367 NZ_CP058656:c4207375-4207079 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References