Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2345055..2345564 Replicon chromosome
Accession NZ_CP043847
Organism Staphylococcus epidermidis strain NCCP 16828

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag F1614_RS11305 Protein ID WP_002474591.1
Coordinates 2345361..2345564 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag F1614_RS11300 Protein ID WP_001829893.1
Coordinates 2345055..2345348 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1614_RS11275 2340063..2340851 + 789 WP_002498781.1 hydroxyethylthiazole kinase -
F1614_RS11280 2340857..2341495 + 639 WP_032605303.1 thiamine phosphate synthase -
F1614_RS11285 2341584..2342456 + 873 WP_158171953.1 membrane protein insertase YidC -
F1614_RS11290 2342562..2343215 - 654 WP_002498779.1 HD domain-containing protein -
F1614_RS11295 2343397..2344881 - 1485 WP_017464703.1 cardiolipin synthase -
F1614_RS11300 2345055..2345348 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
F1614_RS11305 2345361..2345564 + 204 WP_002474591.1 heavy-metal-associated domain-containing protein Toxin
F1614_RS11310 2345707..2345844 + 138 WP_001829949.1 hypothetical protein -
F1614_RS11315 2345943..2347154 - 1212 WP_002474606.1 rod shape-determining protein RodA -
F1614_RS11320 2347545..2348618 + 1074 WP_158171954.1 D-alanine--D-alanine ligase -
F1614_RS11325 2348630..2349985 + 1356 WP_158171955.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7768.94 Da        Isoelectric Point: 6.4587

>T139366 WP_002474591.1 NZ_CP043847:2345361-2345564 [Staphylococcus epidermidis]
MKKGLIHVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 204 bp

>T139366 NZ_CP058656:3866744-3866953 [Escherichia coli]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT139366 WP_001829893.1 NZ_CP043847:2345055-2345348 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT139366 NZ_CP058656:c3866752-3866695 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References