Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2334855..2335364 Replicon chromosome
Accession NZ_CP043845
Organism Staphylococcus epidermidis strain ATCC 12228

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag F1613_RS11380 Protein ID WP_001829980.1
Coordinates 2334855..2335064 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag F1613_RS11385 Protein ID WP_001829893.1
Coordinates 2335071..2335364 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1613_RS11360 2330434..2331789 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
F1613_RS11365 2331801..2332874 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
F1613_RS11370 2333265..2334476 + 1212 WP_002486299.1 rod shape-determining protein RodA -
F1613_RS11375 2334575..2334712 - 138 WP_001829949.1 hypothetical protein -
F1613_RS11380 2334855..2335064 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
F1613_RS11385 2335071..2335364 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
F1613_RS11390 2335538..2337022 + 1485 WP_002457116.1 cardiolipin synthase -
F1613_RS11395 2337204..2337857 + 654 WP_001829983.1 HD domain-containing protein -
F1613_RS11400 2337963..2338835 - 873 WP_002470121.1 membrane protein insertase YidC -
F1613_RS11405 2338924..2339562 - 639 WP_002505076.1 thiamine phosphate synthase -
F1613_RS11410 2339568..2340356 - 789 WP_002469583.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T139364 WP_001829980.1 NZ_CP043845:c2335064-2334855 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T139364 NZ_CP058656:2626014-2626121 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT139364 WP_001829893.1 NZ_CP043845:c2335364-2335071 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT139364 NZ_CP058656:c2625961-2625900 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References