Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2323650..2324179 Replicon chromosome
Accession NZ_CP043845
Organism Staphylococcus epidermidis strain ATCC 12228

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag F1613_RS11320 Protein ID WP_001829891.1
Coordinates 2323650..2324012 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag F1613_RS11325 Protein ID WP_001829931.1
Coordinates 2324009..2324179 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1613_RS11300 2320652..2321422 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
F1613_RS11305 2321397..2321876 - 480 WP_001829903.1 anti-sigma B factor RsbW -
F1613_RS11310 2321878..2322204 - 327 WP_001829952.1 anti-sigma factor antagonist -
F1613_RS11315 2322304..2323305 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
F1613_RS11320 2323650..2324012 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F1613_RS11325 2324009..2324179 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
F1613_RS11330 2324266..2325414 - 1149 WP_002457107.1 alanine racemase -
F1613_RS11335 2325481..2325834 - 354 WP_002457108.1 holo-ACP synthase -
F1613_RS11340 2325882..2326391 - 510 WP_002457109.1 PH domain-containing protein -
F1613_RS11345 2326378..2327883 - 1506 WP_002457110.1 PH domain-containing protein -
F1613_RS11350 2327876..2328355 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T139363 WP_001829891.1 NZ_CP043845:c2324012-2323650 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T139363 NZ_CP058656:2625478-2625585 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT139363 WP_001829931.1 NZ_CP043845:c2324179-2324009 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT139363 NZ_CP058656:c2625431-2625365 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References