139361

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2046100..2046577 Replicon chromosome
Accession NZ_CP043843
Organism Staphylococcus aureus strain NCCP 16830

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag F1612_RS10335 Protein ID WP_000052076.1
Coordinates 2046389..2046577 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag F1612_RS10330 Protein ID WP_001059690.1
Coordinates 2046100..2046360 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1612_RS10295 2041493..2042209 - 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -
F1612_RS10300 2042357..2042779 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
F1612_RS10305 2043178..2043672 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
F1612_RS10310 2043827..2044444 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
F1612_RS10315 2044517..2045098 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
F1612_RS10320 2045323..2045559 + 237 WP_000368687.1 hypothetical protein -
F1612_RS10325 2045556..2045759 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
F1612_RS10330 2046100..2046360 + 261 WP_001059690.1 hypothetical protein Antitoxin
F1612_RS10335 2046389..2046577 + 189 WP_000052076.1 hypothetical protein Toxin
F1612_RS10340 2046765..2047334 + 570 WP_001106652.1 hypothetical protein -
F1612_RS10345 2047422..2047706 + 285 WP_001004394.1 hypothetical protein -
F1612_RS10350 2047768..2047986 + 219 WP_000005884.1 hypothetical protein -
F1612_RS10355 2048481..2048681 - 201 WP_001059082.1 cold-shock protein -
F1612_RS10360 2049038..2049724 - 687 WP_001792695.1 thermonuclease family protein -
F1612_RS10365 2050065..2050586 - 522 WP_042909090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T139361 WP_000052076.1 NZ_CP043843:2046389-2046577 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T139361 NZ_CP058656:2002438-2002541 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT139361 WP_001059690.1 NZ_CP043843:2046100-2046360 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT139361 NZ_CP058656:c2002579-2002308 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References